{"id":"W4400004854","doi":"10.1128/mbio.01031-24","title":"Brilacidin, a novel antifungal agent against <i>Cryptococcus neoformans</i>","year":2024,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; RIKEN; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Azrieli Foundation; Conselho Nacional de Desenvolvimento Científico e Tecnológico; National Institutes of Health; Yonsei University; Fundação de Amparo à Pesquisa do Estado de São Paulo; International Development Research Centre; Canadian Institute for Advanced Research","keywords":"Cryptococcus neoformans; Antifungal; Microbiology; Cryptococcosis; Cryptococcus; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006841706,0.0003462231,0.0001747157,0.0002201863,0.0001746849,0.0001779629,0.0002276266,0.0002816071,0.001110127],"category_scores_gemma":[0.00005387122,0.00006934419,0.0001868363,0.0001184297,0.0001281813,0.0001734141,0.0001497477,0.0003823668,0.0003692721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845773,"about_ca_system_score_gemma":0.0001891901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003943402,"about_ca_topic_score_gemma":0.0004061598,"domain_scores_codex":[0.999959,0.000007330028,0.000003847565,0.000008895739,0.00001087226,0.00001009981],"domain_scores_gemma":[0.9999692,0.000002620292,0.00000879168,0.000002314849,0.000006250879,0.00001077268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002519736,0.00009918962,0.000154034,0.0001879529,0.000008330579,0.0001886308,0.000009681333,0.000140617,0.9901631,0.000130822,0.0003851481,0.008280407],"study_design_scores_gemma":[0.0001470794,0.002819635,0.003552186,0.00004491564,0.00007416221,0.002228812,0.00002058562,0.001045119,0.9636393,0.00008133908,0.02632586,0.00002094718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.956085,0.0273846,0.004138245,0.0006912751,0.0003308803,0.0001809833,0.0007504228,0.0002760759,0.01016238],"genre_scores_gemma":[0.9787896,0.007444221,0.007590155,0.0004461577,0.00008129911,0.00006109822,0.0007753816,0.00001828716,0.004793746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001110127,"threshold_uncertainty_score":0.003713787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02348666902038176,"score_gpt":0.2841358432825226,"score_spread":0.2606491742621408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}