{"id":"W4400005137","doi":"10.1002/adma.202405930","title":"High‐Lactate‐Metabolizing Photosynthetic Bacteria Reprogram Tumor Immune Microenvironment","year":2024,"lang":"en","type":"article","venue":"Advanced Materials","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Hebei University; Science Fund for Creative Research Groups; Natural Science Foundation of Hebei Province; National Natural Science Foundation of China","keywords":"Tumor microenvironment; Immunotherapy; Immune system; Reprogramming; Biology; Cancer research; Bacteria; Tumor cells; Cell; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001730059,0.0002062818,0.0002233943,0.00004148915,0.00006667759,0.0001379755,0.0001437091,0.00004985448,0.0004855149],"category_scores_gemma":[0.00003301313,0.0001801308,0.0000820902,0.00005826663,0.00006734472,0.0000114058,0.0001431696,0.00004653566,0.0001948046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000578753,"about_ca_system_score_gemma":0.00005036936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001230267,"about_ca_topic_score_gemma":0.00001286222,"domain_scores_codex":[0.9986166,0.00005614272,0.0002601131,0.0005191068,0.0001542282,0.000393761],"domain_scores_gemma":[0.9993917,0.000007932907,0.00005062708,0.0004372259,0.00002159324,0.00009092147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002316015,0.00005695113,0.000008761399,0.00006641806,0.0001044146,0.00005875343,0.00001372536,0.000005968097,0.9903556,0.0000397185,0.0001214818,0.008936582],"study_design_scores_gemma":[0.0004430908,0.0001964132,0.0003805263,0.00005968367,0.00002412632,0.0000377476,0.00001238083,5.70606e-7,0.8864879,0.0001382225,0.1120565,0.000162852],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932919,0.005044931,0.00006356119,0.00007927165,0.0007452594,0.0004028971,0.0002142443,0.0000533794,0.0001045768],"genre_scores_gemma":[0.9947358,0.001673505,0.002108745,0.00005724297,0.0002022699,0.0002564795,0.0003349546,0.00005598097,0.0005750625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.111935,"threshold_uncertainty_score":0.7345521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005501661381210553,"score_gpt":0.2617906552322343,"score_spread":0.2562889938510237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}