{"id":"W4400016033","doi":"10.1111/bph.16481","title":"The contribution of Na<sub>V</sub>1.6 to the efficacy of voltage‐gated sodium channel inhibitors in wild type and Na<sub>V</sub>1.6 gain‐of‐function (GOF) mouse seizure control","year":2024,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Sodium channel; Gene isoform; Sodium channel blocker; Chemistry; Pharmacology; Inhibitory postsynaptic potential; Epilepsy; Sodium; Neuroscience; Medicine; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950421,0.0003604895,0.0004641741,0.0002782211,0.00009457924,0.0003709596,0.0002965471,0.0003246524,0.0008978825],"category_scores_gemma":[0.0002870667,0.0001734558,0.0002405316,0.00008897956,0.0002633428,0.0003299331,0.0001178572,0.000652226,0.0002130315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003470531,"about_ca_system_score_gemma":0.0001998221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005015178,"about_ca_topic_score_gemma":0.0009124216,"domain_scores_codex":[0.9998098,0.00002101757,0.00002515683,0.00003170631,0.00006449496,0.00004788463],"domain_scores_gemma":[0.9997836,0.00003579786,0.00008295589,0.00001395972,0.00002166811,0.00006205327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005299518,0.0000866109,0.0004323029,0.00003817075,0.00001057704,0.00003012629,0.000006481134,0.0001383407,0.996474,0.00007424554,0.00004387046,0.002135367],"study_design_scores_gemma":[0.00008290278,0.002690518,0.006714399,0.000008765967,0.00006355474,0.0003346657,0.00002020229,0.001033037,0.9881561,0.00006264662,0.0008244946,0.000008733366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965361,0.001126487,0.0006489319,0.00006810941,0.00002317746,0.00002748323,0.0003513776,0.00005007,0.001168207],"genre_scores_gemma":[0.9965801,0.0009020211,0.00106553,0.00004721447,0.00001196024,0.00002997213,0.0003148399,0.00002047158,0.001027907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008978825,"threshold_uncertainty_score":0.003003716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744437994186479,"score_gpt":0.2998045980522499,"score_spread":0.2823602181103851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}