{"id":"W4400018508","doi":"10.1021/acs.jmedchem.3c02164","title":"Development of a Potent and Selective G2A (GPR132) Agonist","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; Cardio-Pulmonary Institute; Taras Shevchenko National University of Kyiv; Enamine; Universität Leipzig; European Commission; Kungliga Tekniska Högskolan; Deutschen Konsortium für Translationale Krebsforschung; McGill University; Cancer Research Institute; European Federation of Pharmaceutical Industries and Associations; Diamond Light Source; Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum","keywords":"Chemistry; Agonist; Pharmacology; Stereochemistry; Receptor; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126934,0.0002390854,0.0002274735,0.0001754374,0.0001104323,0.0001271333,0.0002172182,0.0002299007,0.001510525],"category_scores_gemma":[0.00006608182,0.000137275,0.0001728917,0.0001602309,0.00008656063,0.0001252151,0.0001979596,0.0003427413,0.0003859497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001170731,"about_ca_system_score_gemma":0.0002248561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002657697,"about_ca_topic_score_gemma":0.0006398601,"domain_scores_codex":[0.9999506,0.000008011837,0.000003525358,0.00001034018,0.00001167842,0.00001568924],"domain_scores_gemma":[0.9999821,0.000001978126,0.000005527217,0.000001487461,0.000003063296,0.00000588083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002492113,0.0001330005,0.0001425147,0.00005940221,0.000007080516,0.0001239586,0.00001436381,0.0002033693,0.9900271,0.0001201996,0.0002794376,0.008640284],"study_design_scores_gemma":[0.0004731914,0.00706662,0.003683056,0.00001469008,0.00005820195,0.001116543,0.00004001123,0.00190536,0.9744271,0.00008717363,0.01110972,0.00001823083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877312,0.001990984,0.005742322,0.0003469541,0.0000495113,0.0001923662,0.0005963245,0.0001535372,0.003196942],"genre_scores_gemma":[0.9812027,0.002969415,0.01077514,0.0002638808,0.00002876738,0.0001231368,0.001075574,0.00001998087,0.003541424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510525,"threshold_uncertainty_score":0.005053222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182580438211795,"score_gpt":0.2845916978047006,"score_spread":0.2727658934225826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}