{"id":"W4400024406","doi":"10.17615/8eax-6c71","title":"Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women","year":2024,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Sex and Gender in Healthcare","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Health and Medical Research Council; Medical Research Council; Centers for Disease Control and Prevention; Deutschen Konsortium für Translationale Krebsforschung; Institut Gustave-Roussy; Cancer Council Victoria; Deutsche Krebshilfe; Vetenskapsrådet; Cancerfonden; Institut National de la Santé et de la Recherche Médicale; Programme Grants for Applied Research; McGill University; Deutsche Forschungsgemeinschaft; Robert Bosch Stiftung; Bundesministerium für Bildung und Forschung; Swedish Cancer Foundation; Mutuelle Générale de l'Education Nationale; Ministerio de Economía y Competitividad; National Institutes of Health; Deutsche Gesetzliche Unfallversicherung; David F. and Margaret T. Grohne Family Foundation; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; Associazione Italiana per la Ricerca sul Cancro; Lon V. Smith Foundation; Génome Québec; Eberhard Karls Universität Tübingen; Agency for Science, Technology and Research; European Commission; Breast Cancer Research Foundation; World Cancer Research Fund; Susan G. Komen for the Cure; Cancer Research UK; U.S. Department of Health and Human Services","keywords":"Breast cancer; Hormone therapy; Oncology; Medicine; Internal medicine; Cancer; Gynecology; Obstetrics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000142049,0.0001374756,0.0003467118,0.0003879819,0.00006774119,0.0001332263,0.00004783004,0.00007918646,0.0004828958],"category_scores_gemma":[0.00005033878,0.0001043428,0.00005338897,0.0007104995,0.0001283037,0.0006342079,0.0000349474,0.0001986167,0.000002725324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006970605,"about_ca_system_score_gemma":0.0001472639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001925941,"about_ca_topic_score_gemma":0.0001143037,"domain_scores_codex":[0.9990031,0.00006163259,0.0002572733,0.000293162,0.0001809074,0.0002039448],"domain_scores_gemma":[0.9991923,0.0002749181,0.00006898946,0.0002361914,0.00006271275,0.000164906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007060635,0.00005197235,0.9564646,0.0001580274,0.003686458,0.00002498763,0.01784166,0.00003346903,0.001702212,0.0005259207,0.0008096569,0.0179949],"study_design_scores_gemma":[0.000304205,0.0002262624,0.9896908,0.00005169626,0.0004755111,0.000005736678,0.002256893,0.0005048726,0.0005440561,0.0009772576,0.004860855,0.0001018071],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847668,0.01317911,0.00006001119,0.001207996,0.0001692948,0.0001785477,0.0002017741,0.00009247164,0.0001439303],"genre_scores_gemma":[0.9951327,0.003397622,0.0001990321,0.0003657444,0.0001668115,0.00003915663,0.00007410214,0.00002355585,0.0006012423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03322618,"threshold_uncertainty_score":0.5287371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512978900281746,"score_gpt":0.2934108319429375,"score_spread":0.2582810429401201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}