{"id":"W4400024406","doi":"10.17615/8eax-6c71","title":"Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women","year":2024,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Sex and Gender in Healthcare","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Health and Medical Research Council; Medical Research Council; Centers for Disease Control and Prevention; Deutschen Konsortium für Translationale Krebsforschung; Institut Gustave-Roussy; Cancer Council Victoria; Deutsche Krebshilfe; Vetenskapsrådet; Cancerfonden; Institut National de la Santé et de la Recherche Médicale; Programme Grants for Applied Research; McGill University; Deutsche Forschungsgemeinschaft; Robert Bosch Stiftung; Bundesministerium für Bildung und Forschung; Swedish Cancer Foundation; Mutuelle Générale de l'Education Nationale; Ministerio de Economía y Competitividad; National Institutes of Health; Deutsche Gesetzliche Unfallversicherung; David F. and Margaret T. Grohne Family Foundation; Deutsches Krebsforschungszentrum; Ligue Contre le Cancer; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; Associazione Italiana per la Ricerca sul Cancro; Lon V. Smith Foundation; Génome Québec; Eberhard Karls Universität Tübingen; Agency for Science, Technology and Research; European Commission; Breast Cancer Research Foundation; World Cancer Research Fund; Susan G. Komen for the Cure; Cancer Research UK; U.S. Department of Health and Human Services","keywords":"Breast cancer; Hormone therapy; Oncology; Medicine; Internal medicine; Cancer; Gynecology; Obstetrics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001729248,0.0004288782,0.0008314934,0.001017793,0.0005875508,0.0007201792,0.0005295913,0.000569277,0.001932976],"category_scores_gemma":[0.003897832,0.0004389388,0.002162695,0.002044197,0.0003527865,0.0002580807,0.0005758615,0.0005648454,0.0001359441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003454396,"about_ca_system_score_gemma":0.0004211997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01255122,"about_ca_topic_score_gemma":0.01598893,"domain_scores_codex":[0.9983408,0.0005568154,0.000163072,0.000622283,0.000144764,0.0001722926],"domain_scores_gemma":[0.9975532,0.001330879,0.0004747368,0.0003310097,0.0001228388,0.0001874279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001831139,0.00003709821,0.9869131,0.00008509401,0.005510144,0.0002424549,0.0001244909,0.0002188502,0.002316807,0.00006854033,0.0002333806,0.002418857],"study_design_scores_gemma":[0.0000993762,0.0002022661,0.9949533,0.00001371344,0.002952552,0.0002357244,0.0001026076,0.0006186958,0.0002414468,0.0001020978,0.0004676601,0.00001054902],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960555,0.001700477,0.0005587558,0.00009385941,0.00001762974,0.00001129134,0.001341059,0.00002001556,0.0002014503],"genre_scores_gemma":[0.9983522,0.0002481553,0.0003180445,0.00003402414,0.00001496645,0.00002032725,0.0008506512,0.000007529393,0.0001541696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01255122,"threshold_uncertainty_score":0.02495635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512978900281746,"score_gpt":0.2934108319429375,"score_spread":0.2582810429401201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}