{"id":"W4400024415","doi":"10.17615/q2rq-dt33","title":"Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study","year":2024,"lang":"en","type":"article","venue":"Kölner Universitäts PublikationsServer (Universität zu Köln)","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Servicio Gallego de Salud; Instituto de Salud Carlos III; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Programme Grants for Applied Research; Manchester Biomedical Research Centre; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Deutschen Konsortium für Translationale Krebsforschung; Xunta de Galicia; Ministero dello Sviluppo Economico; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; University of Crete; Syöpäsäätiö; Vetenskapsrådet; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Fonds Wetenschappelijk Onderzoek; European Regional Development Fund; Daiichi-Sankyo; Universitätsklinikum Hamburg-Eppendorf; Russian Foundation for Basic Research; Cancer Council Western Australia; European Commission; Cancerfonden; National Cancer Institute; University College London; Cancer Institute NSW; Fondation de France; University of Utah; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Breast Cancer Campaign; Ministerio de Sanidad, Servicios Sociales e Igualdad; University of Cambridge; Government of Canada; Ministerio de Economía y Competitividad; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; National Breast Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Swedish Cancer Foundation; Eli Lilly and Company; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Cancer Research UK; Memorial Sloan-Kettering Cancer Center; Fondation du cancer du sein du Québec; Wellcome Trust; McGill University Health Centre; Kreftforeningen; David F. and Margaret T. Grohne Family Foundation; Robert Bosch Stiftung; Huntsman Cancer Foundation; Deutsches Krebsforschungszentrum; Deutsche Gesetzliche Unfallversicherung; Deutsche Forschungsgemeinschaft; Breast Cancer Research Foundation; McGill University; National Institute for Health and Care Research; Norges Forskningsråd; Division of Cancer Prevention, National Cancer Institute; Karolinska Institutet; Harvard T.H. Chan School of Public Health; Institut National Du Cancer; Leids Universitair Medisch Centrum; Myriad Genetics; Université Laval; Cancer Council Victoria; Ministry of Science and Higher Education of the Russian Federation; Celgene; Genome Canada; Itä-Suomen Yliopisto; Brigham and Women's Hospital; Eberhard Karls Universität Tübingen; Intermountain Healthcare; U.S. Department of Health and Human Services; Freistaat Sachsen; Huntsman Cancer Institute; Agence Nationale de la Recherche; Rheinische Friedrich-Wilhelms-Universität Bonn; Oak Foundation; Pfizer; Amgen","keywords":"Breast cancer; Mendelian inheritance; Physical activity; Medicine; Oncology; Internal medicine; Demography; Cancer; Physical therapy; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001617976,0.0002751981,0.0002133124,0.0003630315,0.0004599767,0.0002019372,0.000254836,0.0001253962,0.0003340782],"category_scores_gemma":[0.00001127011,0.0003079594,0.0001735436,0.0004829611,0.0001288472,0.0003582385,0.0002609671,0.0001672677,0.00004265037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001304557,"about_ca_system_score_gemma":0.0002428675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006407825,"about_ca_topic_score_gemma":0.0004546179,"domain_scores_codex":[0.9984016,0.0002048848,0.0001119591,0.0007049827,0.0002831251,0.0002934582],"domain_scores_gemma":[0.9990895,0.0000347582,0.00008075098,0.0003583559,0.0001755841,0.0002610214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01876709,0.01874143,0.2878102,0.001223636,0.01617843,0.001202111,0.02512507,0.005482215,0.2986377,0.01027606,0.1878224,0.1287336],"study_design_scores_gemma":[0.05684093,0.002619071,0.777605,0.0003742955,0.008909112,0.0002236432,0.0278898,0.04360176,0.008848775,0.003446982,0.06430736,0.005333251],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994944,0.0004822436,0.0004569532,0.001652023,0.000215822,0.0006503555,0.0006123349,0.0001013205,0.0008849273],"genre_scores_gemma":[0.993591,0.0002886209,0.00007535318,0.00006368623,0.0003400015,0.00001093035,0.0003259167,0.00003452503,0.005270033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4897948,"threshold_uncertainty_score":0.9999372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005706360205425354,"score_gpt":0.2297060024898794,"score_spread":0.223999642284454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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