{"id":"W4400024441","doi":"10.17615/mt16-xj68","title":"Combined Associations of a Polygenic Risk Score and Classical Risk Factors with Breast Cancer Risk","year":2024,"lang":"en","type":"article","venue":"Edinburgh Research Explorer (University of Edinburgh)","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research and Materiel Command; National Heart, Lung, and Blood Institute; Universitätsklinikum Hamburg-Eppendorf; Programme Grants for Applied Research; Instituto de Salud Carlos III; Cancer Council Tasmania; National Health and Medical Research Council; Medical Research Council; Institut National Du Cancer; Centers for Disease Control and Prevention; Hellenic Health Foundation; Rheinische Friedrich-Wilhelms-Universität Bonn; Institut Gustave-Roussy; Deutsche Krebshilfe; Swedish Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Vetenskapsrådet; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Institut National de la Santé et de la Recherche Médicale; Cancer Australia; Agence Nationale de la Recherche; Breast Cancer Research Foundation; McGill University; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Cancer Council South Australia; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; National Breast Cancer Foundation; University of Cambridge; Cancer Research UK; Division of Cancer Prevention, National Cancer Institute; National Institute for Health and Care Research; Associazione Italiana per la Ricerca sul Cancro; Lon V. Smith Foundation; U.S. Army; U.S. Department of Health and Human Services; Mayo Clinic; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Agency for Science, Technology and Research; Deutschen Konsortium für Translationale Krebsforschung; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Sundhed og Sygdom, Det Frie Forskningsråd; Cancer Council Victoria; California Department of Public Health; European Commission; World Cancer Research Fund; Stavros Niarchos Foundation; Cancer Council NSW; Susan G. Komen for the Cure","keywords":"Polygenic risk score; Breast cancer; Medicine; Oncology; Demography; Cancer; Internal medicine; Biology; Genetics; Single-nucleotide polymorphism; Gene; Genotype; Sociology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001847888,0.0005542672,0.0005685136,0.001214877,0.0003175597,0.000587867,0.0004582194,0.0004900465,0.001927268],"category_scores_gemma":[0.005821052,0.0002728241,0.000937153,0.001565643,0.0005100296,0.0003091826,0.0006897348,0.0005057134,0.000210869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001891405,"about_ca_system_score_gemma":0.0002470632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003844214,"about_ca_topic_score_gemma":0.004684512,"domain_scores_codex":[0.9981376,0.0009454885,0.0001175163,0.0003533405,0.0002959598,0.000150136],"domain_scores_gemma":[0.995598,0.002103723,0.000840424,0.000765476,0.0002801505,0.0004122536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005296075,0.00002464049,0.9935054,0.00001145683,0.0006354428,0.0001419625,0.00003931055,0.0002986919,0.001457285,0.0000706728,0.00004961018,0.003235859],"study_design_scores_gemma":[0.00001301932,0.0001348113,0.9974977,0.000002269764,0.0001667715,0.0003642968,0.00002801544,0.00130918,0.0001903753,0.0001738444,0.0001124136,0.000007257077],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984407,0.0002003287,0.0008742224,0.00003065374,0.000004669038,0.00000529302,0.000203062,0.00001357645,0.0002275293],"genre_scores_gemma":[0.9992324,0.00003643393,0.0004076815,0.000006218997,0.0000067233,0.000003211154,0.0001892555,0.000004090176,0.0001141494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003844214,"threshold_uncertainty_score":0.009772718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03759516769058894,"score_gpt":0.2906114617229196,"score_spread":0.2530162940323306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}