{"id":"W4400024448","doi":"10.17615/c9rj-vf19","title":"Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment","year":2024,"lang":"en","type":"article","venue":"UNC Libraries","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research and Materiel Command; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council Tasmania; Cancer Council NSW; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Programme Grants for Applied Research; Manchester Biomedical Research Centre; University of California, San Francisco; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Centers for Disease Control and Prevention; Leids Universitair Medisch Centrum; Institut National Du Cancer; Norges Forskningsråd; Deutsche Krebshilfe; Institut National de la Santé et de la Recherche Médicale; University of Crete; Vetenskapsrådet; Stockholms Läns Landsting; University of Southern California; Stavros Niarchos Foundation; Kuopion Yliopistollinen Sairaala; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Government of Canada; Ministerio de Sanidad, Servicios Sociales e Igualdad; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; Ministerio de Economía y Competitividad; Cancer Australia; Agence Nationale de la Recherche; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Cancer Council South Australia; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; European Regional Development Fund; King's College London; National Institute for Health and Care Research; Cancer Research UK; Robert Bosch Stiftung; Eberhard Karls Universität Tübingen; Rheinische Friedrich-Wilhelms-Universität Bonn; Breast Cancer Research Trust; Fondation du cancer du sein du Québec; David F. and Margaret T. Grohne Family Foundation; U.S. Army; University of Westminster; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Brigham and Women's Hospital; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Itä-Suomen Yliopisto; Fondation de France; Sundhed og Sygdom, Det Frie Forskningsråd; Cancer Council Victoria; California Department of Public Health; National Breast Cancer Foundation; Cancer Council Western Australia; European Commission; Breast Cancer Research Foundation","keywords":"Germline; Pathological; Breast cancer; Oncology; Biology; Cancer; Genetic association; Internal medicine; Medicine; Genetics; Genotype; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233406,0.0001372717,0.0002610637,0.00006905423,0.00002082182,0.00001945414,0.00007378403,0.0001506811,0.00005039001],"category_scores_gemma":[0.00004290911,0.0001041106,0.00002805125,0.0002730066,0.00008110879,0.000008030753,0.00005564012,0.00005386574,0.000001830135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009386523,"about_ca_system_score_gemma":0.0002631991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007812672,"about_ca_topic_score_gemma":0.00004751749,"domain_scores_codex":[0.99892,0.0001295361,0.0003781337,0.000337041,0.00008016718,0.0001551387],"domain_scores_gemma":[0.9994927,0.00009138486,0.0001291571,0.0001670608,0.00008214901,0.00003753755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00124316,0.0003946432,0.4941479,0.0001983991,0.0005910278,0.00003202142,0.001344192,0.000608101,0.4851353,0.005906397,0.002094963,0.00830385],"study_design_scores_gemma":[0.009148166,0.01727851,0.6700759,0.001597949,0.0007384609,0.000553778,0.002285072,0.0008940138,0.2653368,0.01143296,0.01848767,0.002170722],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861787,0.01212601,0.0002615346,0.0003170269,0.0002859406,0.0002329182,0.0005105972,0.0000138763,0.00007341796],"genre_scores_gemma":[0.9958831,0.000605902,0.003035203,0.00002798247,0.00003796789,0.00004801613,0.0001597032,0.00001917355,0.0001829612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2197985,"threshold_uncertainty_score":0.4245509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188290430788302,"score_gpt":0.256010323735061,"score_spread":0.244127419427178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}