{"id":"W4400024448","doi":"10.17615/c9rj-vf19","title":"Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment","year":2024,"lang":"en","type":"article","venue":"UNC Libraries","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research and Materiel Command; Servicio Gallego de Salud; Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council Tasmania; Cancer Council NSW; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Canadian Institutes of Health Research; Programme Grants for Applied Research; Manchester Biomedical Research Centre; University of California, San Francisco; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Centers for Disease Control and Prevention; Leids Universitair Medisch Centrum; Institut National Du Cancer; Norges Forskningsråd; Deutsche Krebshilfe; Institut National de la Santé et de la Recherche Médicale; University of Crete; Vetenskapsrådet; Stockholms Läns Landsting; University of Southern California; Stavros Niarchos Foundation; Kuopion Yliopistollinen Sairaala; Harvard T.H. Chan School of Public Health; Karolinska Institutet; Government of Canada; Ministerio de Sanidad, Servicios Sociales e Igualdad; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; Ministerio de Economía y Competitividad; Cancer Australia; Agence Nationale de la Recherche; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Cancer Council South Australia; Fonds Wetenschappelijk Onderzoek; Cancerfonden; National Cancer Institute; Cancer Institute NSW; European Regional Development Fund; King's College London; National Institute for Health and Care Research; Cancer Research UK; Robert Bosch Stiftung; Eberhard Karls Universität Tübingen; Rheinische Friedrich-Wilhelms-Universität Bonn; Breast Cancer Research Trust; Fondation du cancer du sein du Québec; David F. and Margaret T. Grohne Family Foundation; U.S. Army; University of Westminster; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Brigham and Women's Hospital; Associazione Italiana per la Ricerca sul Cancro; Genome Canada; Itä-Suomen Yliopisto; Fondation de France; Sundhed og Sygdom, Det Frie Forskningsråd; Cancer Council Victoria; California Department of Public Health; National Breast Cancer Foundation; Cancer Council Western Australia; European Commission; Breast Cancer Research Foundation","keywords":"Germline; Pathological; Breast cancer; Oncology; Biology; Cancer; Genetic association; Internal medicine; Medicine; Genetics; Genotype; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001029621,0.0002730115,0.0004664024,0.0004922349,0.0002984759,0.0004494392,0.0002866419,0.0005063103,0.001200199],"category_scores_gemma":[0.002756724,0.0001345989,0.0008688925,0.0005486126,0.0003527452,0.0001824127,0.0003449574,0.0004368631,0.0001079351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001755342,"about_ca_system_score_gemma":0.0002291433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001327005,"about_ca_topic_score_gemma":0.001829166,"domain_scores_codex":[0.9991688,0.0001857253,0.00007499394,0.0003382044,0.00009764585,0.000134604],"domain_scores_gemma":[0.9975142,0.001084079,0.0008623722,0.0002686938,0.00008779347,0.0001828829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007615488,0.0000209525,0.9937322,0.00001020864,0.000474336,0.0001234782,0.00004651615,0.0003106794,0.002531416,0.00003577254,0.00005098467,0.001901898],"study_design_scores_gemma":[0.000043264,0.0001864228,0.9968088,0.000004153262,0.0003026084,0.000625311,0.00005738051,0.001102004,0.0005260936,0.0001989421,0.0001384449,0.00000655142],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994057,0.0001383124,0.000209619,0.00001685799,0.000002381879,0.000002318888,0.0001317987,0.000003152785,0.00008986526],"genre_scores_gemma":[0.9997527,0.00001535898,0.0000584577,0.000008787947,0.000002651359,0.000002039221,0.0001365168,0.000001648291,0.00002179723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327005,"threshold_uncertainty_score":0.005445242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188290430788302,"score_gpt":0.256010323735061,"score_spread":0.244127419427178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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