{"id":"W4400024471","doi":"10.17615/dprd-7a14","title":"A network analysis to identify mediators of germline-driven differences in breast cancer prognosis","year":2024,"lang":"en","type":"article","venue":"Research Explorer (The University of Manchester)","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Servicio Gallego de Salud; Instituto de Salud Carlos III; Medical Research Council; Canadian Institutes of Health Research; Programme Grants for Applied Research; Manchester Biomedical Research Centre; Imperial Experimental Cancer Medicine Centre; National Institutes of Health; Hellenic Health Foundation; Freistaat Sachsen; Federal Agency for Scientific Organizations; Deutschen Konsortium für Translationale Krebsforschung; Xunta de Galicia; Rheinische Friedrich-Wilhelms-Universität Bonn; Mutuelle Générale de l'Education Nationale; Institut Gustave-Roussy; Centers for Disease Control and Prevention; Institut National Du Cancer; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Norges Forskningsråd; Associazione Italiana per la Ricerca sul Cancro; Institut National de la Santé et de la Recherche Médicale; University of Crete; Vetenskapsrådet; Stockholms Läns Landsting; Stavros Niarchos Foundation; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; University of Cambridge; Government of Canada; Ministerio de Sanidad, Servicios Sociales e Igualdad; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Universitätsklinikum Hamburg-Eppendorf; Russian Foundation for Basic Research; Cancer Australia; Agence Nationale de la Recherche; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; Robert Bosch Stiftung; Agency for Science, Technology and Research; University of Westminster; European Regional Development Fund; King's College London; National Institute for Health and Care Research; Genome Canada; National Heart, Lung, and Blood Institute; Itä-Suomen Yliopisto; Lon V. Smith Foundation; Fondation du cancer du sein du Québec; National Breast Cancer Foundation; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Swedish Cancer Foundation; David F. and Margaret T. Grohne Family Foundation; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Breast Cancer Campaign; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Cancer Council Victoria; California Department of Public Health; Sundhed og Sygdom, Det Frie Forskningsråd; Centre International de Recherche sur le Cancer; World Cancer Research Fund; Helsingin ja Uudenmaan Sairaanhoitopiiri; U.S. Department of Health and Human Services; European Commission; Breast Cancer Research Foundation; Cancerfonden; National Cancer Institute; Cancer Institute NSW; Cancer Research UK; American Cancer Society","keywords":"Germline; Breast cancer; Cancer; Oncology; Biology; Computational biology; Medicine; Internal medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00110015,0.0004388146,0.0003665715,0.001912725,0.0003394215,0.000688036,0.0003897207,0.0002811012,0.002009438],"category_scores_gemma":[0.005261334,0.0001590165,0.0007642665,0.001709679,0.0002434677,0.0004455538,0.0005377162,0.0004125644,0.0001710454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006754813,"about_ca_system_score_gemma":0.0006252174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004992568,"about_ca_topic_score_gemma":0.005881004,"domain_scores_codex":[0.9994985,0.0002619266,0.00002277741,0.0001301085,0.00004630622,0.00004033807],"domain_scores_gemma":[0.996777,0.002433024,0.0003578129,0.0001650399,0.0001536925,0.0001135703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0011828,0.0003573966,0.5178215,0.0005493306,0.003576082,0.000810568,0.00050284,0.2832937,0.02562062,0.02307205,0.005951222,0.1372619],"study_design_scores_gemma":[0.00007226846,0.0001756783,0.1428094,0.0000410078,0.0005539053,0.0002978552,0.0001712247,0.8206362,0.00198981,0.03003288,0.003190969,0.00002886748],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7759181,0.001304766,0.2091071,0.001742028,0.000064612,0.0001347932,0.008274812,0.0008145454,0.0026392],"genre_scores_gemma":[0.9628398,0.0003281552,0.03267477,0.00006982883,0.00002899783,0.0001028667,0.003309177,0.00002971481,0.0006167126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004992568,"threshold_uncertainty_score":0.009927034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03683232421174241,"score_gpt":0.3049811378830769,"score_spread":0.2681488136713345,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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