{"id":"W4400024503","doi":"10.17615/g8tn-rh62","title":"Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers","year":2024,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Medical Research Council; Canadian Institutes of Health Research; Canadian Cancer Society Research Institute; National Institutes of Health; Herlev Hospital; Fundação de Amparo à Pesquisa do Estado de São Paulo; Princess Margaret Hospital Foundation; National Institute for Health and Care Research; National Institute of Dental and Craniofacial Research; Universidad de Oviedo; Vanderbilt University; Moffitt Cancer Center; Norges Forskningsråd; Vanderbilt University Medical Center; National Cancer Institute; Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología; University of Pittsburgh; Cancer Care Ontario; National Center for Research Resources; Medical Research and Materiel Command; Georgia Clinical and Translational Science Alliance; Sundhed og Sygdom, Det Frie Forskningsråd; Roy Castle Lung Cancer Foundation; U.S. Department of Defense","keywords":"Mendelian randomization; Telomere; Oncology; Medicine; Head and neck; Lung cancer; Internal medicine; Biology; Genetics; Surgery; Genotype; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03777564,0.001099313,0.001193775,0.0009907655,0.0004718897,0.0007978209,0.001742708,0.0007121742,0.003134578],"category_scores_gemma":[0.07518758,0.000426111,0.003762401,0.001086511,0.001411374,0.000677301,0.001213731,0.001301563,0.0001560206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006596014,"about_ca_system_score_gemma":0.001225283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003313065,"about_ca_topic_score_gemma":0.00185031,"domain_scores_codex":[0.9526485,0.04173241,0.0006608044,0.002809572,0.001280336,0.0008684344],"domain_scores_gemma":[0.9229814,0.06354229,0.005868852,0.006294546,0.000859178,0.0004536332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009814397,0.0005137455,0.840398,0.0006181881,0.02321621,0.002063711,0.001365181,0.01542827,0.004538555,0.02393965,0.001682584,0.07642156],"study_design_scores_gemma":[0.004922948,0.007667082,0.5539129,0.0002945395,0.02334351,0.00427313,0.001145199,0.2866614,0.007478118,0.104503,0.005522292,0.0002759627],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8887814,0.001948783,0.1049824,0.00127793,0.0001302859,0.0003752095,0.0006206658,0.0003828962,0.001500365],"genre_scores_gemma":[0.9857773,0.0001608849,0.01339929,0.0001136226,0.00003433366,0.0002200933,0.00009595626,0.00001860782,0.0001799163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03777564,"threshold_uncertainty_score":0.199779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00893271033995084,"score_gpt":0.2452632394704882,"score_spread":0.2363305291305374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}