{"id":"W4400038478","doi":"10.1089/can.2023.0282","title":"Acute Cannabis Administration Transiently Reduces Mitochondrial DNA in Young Adults: Findings from a Secondary Analysis of a Double-Blind, Placebo-Controlled, Randomized Clinical Trial","year":2024,"lang":"en","type":"article","venue":"Cannabis and Cannabinoid Research","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Waypoint Centre for Mental Health Care; Centre for Addiction and Mental Health; Public Health Ontario; University of Toronto","funders":"","keywords":"Placebo; Randomized controlled trial; Administration (probate law); Cannabis; Medicine; Clinical trial; Mitochondrial DNA; Double blind; Anesthesia; Internal medicine; Psychiatry; Biology; Alternative medicine; Genetics; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01051709,0.0007898094,0.004348557,0.004678234,0.0003467151,0.0006483882,0.0006435903,0.0009737639,0.001055733],"category_scores_gemma":[0.001815434,0.000632331,0.002345869,0.005767611,0.002211349,0.0004880228,0.0002474147,0.003033989,0.00001724507],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005712994,"about_ca_system_score_gemma":0.006223646,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009205562,"about_ca_topic_score_gemma":0.01007393,"domain_scores_codex":[0.9876885,0.002253224,0.003489268,0.002311175,0.002540648,0.001717156],"domain_scores_gemma":[0.9955105,0.0004069426,0.0003016202,0.00108343,0.001470493,0.001226999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9095257,0.0008589798,0.0002612438,0.0004031165,0.005483452,0.0005828638,0.003243983,0.000006970739,0.004022447,0.0005376405,0.06736754,0.00770606],"study_design_scores_gemma":[0.9631724,0.003427317,0.002755711,0.0006026241,0.004784122,0.00005577516,0.002192233,0.00609171,0.003861733,0.0001998605,0.01214474,0.0007117402],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9488173,0.005593936,0.00004342951,0.031116,0.001466005,0.01022249,0.0006938503,0.0001058845,0.001941098],"genre_scores_gemma":[0.9645681,0.001832547,0.00008421092,0.000110639,0.00120138,0.0054631,0.0007940464,0.0001286225,0.02581732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05522279,"threshold_uncertainty_score":0.9998574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04211818000223031,"score_gpt":0.397358913994754,"score_spread":0.3552407339925237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}