{"id":"W4400048314","doi":"10.1099/acmi.0.000675.v3","title":"Deciphering the interaction surface between the West Nile virus NS3 and NS5 proteins","year":2024,"lang":"en","type":"article","venue":"Access Microbiology","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"NS3; Virology; Flavivirus; Dengue virus; Flaviviridae; Zika virus; Dengue fever; Japanese encephalitis; In silico; Biology; Viral replication; Virus; Replicon; West Nile virus; Encephalitis; Hepatitis C virus; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001085884,0.000405865,0.0002877481,0.0002188054,0.0002730037,0.0002912048,0.0002823007,0.0003305347,0.001349859],"category_scores_gemma":[0.0001800711,0.0001420426,0.0004652425,0.0001194322,0.000122317,0.0005218317,0.000245622,0.0003285495,0.00028917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003630281,"about_ca_system_score_gemma":0.000228288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002496073,"about_ca_topic_score_gemma":0.002475451,"domain_scores_codex":[0.9999425,0.00001063647,0.00000284706,0.00001082167,0.00001908396,0.00001401807],"domain_scores_gemma":[0.9999703,0.00001220289,0.000006416403,0.000001876864,0.000004766229,0.000004383267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004972305,0.000208158,0.01663327,0.0004002055,0.000155309,0.0008113179,0.0001822376,0.0565456,0.9057556,0.003606167,0.0006547728,0.01455019],"study_design_scores_gemma":[0.00002829671,0.0003296686,0.01738004,0.0000352804,0.0001280329,0.0003552977,0.0003401686,0.7324926,0.2429426,0.002216076,0.003714529,0.00003742565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860946,0.001473856,0.01026209,0.0001297582,0.00001638127,0.00001353779,0.0002025207,0.00006828385,0.001739102],"genre_scores_gemma":[0.9953457,0.0006627095,0.003276776,0.00002151352,0.000002453667,0.000006713025,0.0002931555,0.000008133505,0.0003827373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002496073,"threshold_uncertainty_score":0.00496304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02212078845792223,"score_gpt":0.3226834391324667,"score_spread":0.3005626506745445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}