{"id":"W4400049339","doi":"10.1038/s41556-024-01446-3","title":"Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3","year":2024,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Canadian Institute for Advanced Research; European Molecular Biology Organization; U.S. Department of Health and Human Services","keywords":"Downregulation and upregulation; Histone methyltransferase; Cancer research; Chromatin; Histone H3; Epigenomics; Methyltransferase; Epigenetics; Chromatin immunoprecipitation; Histone; Biology; Carcinogenesis; EZH2; Cell biology; Chemistry; DNA methylation; Methylation; Gene expression; Cancer; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050185,0.0003404751,0.000208541,0.0003488499,0.0001689239,0.0003052145,0.0002176384,0.0002480467,0.001493981],"category_scores_gemma":[0.00009842173,0.0001753151,0.000207763,0.0001938088,0.0002903969,0.0001148692,0.0002365965,0.0005250541,0.0005348445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003892237,"about_ca_system_score_gemma":0.000266092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00119378,"about_ca_topic_score_gemma":0.002473971,"domain_scores_codex":[0.9998389,0.00001687154,0.00001805738,0.00004158844,0.00005616616,0.00002828643],"domain_scores_gemma":[0.9998822,0.00001154119,0.00004245694,0.00001392989,0.00001084184,0.00003903771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006093313,0.00001266317,0.00021394,0.00002286189,0.000004507143,0.00004332636,0.000004993698,0.0000500639,0.9990429,0.00006073588,0.00004368088,0.0004393449],"study_design_scores_gemma":[0.00001710713,0.00008956548,0.005226845,0.000004639832,0.00001199627,0.0004613537,0.00002481926,0.001040629,0.9905095,0.0000532807,0.002556268,0.000003948337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898143,0.0008812775,0.004686819,0.0001958224,0.00003898322,0.00004264403,0.002468457,0.0001917638,0.001680045],"genre_scores_gemma":[0.99172,0.0005110362,0.002688481,0.00005284614,0.000006216706,0.00004613117,0.00134699,0.00004960583,0.003578688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493981,"threshold_uncertainty_score":0.004997909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006699762168171395,"score_gpt":0.2820598114642903,"score_spread":0.2753600492961189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}