{"id":"W4400060535","doi":"10.1002/exp.20240002","title":"A pH responsive nanocomposite for combination sonodynamic‐immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway","year":2024,"lang":"en","type":"article","venue":"Exploration","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"National Natural Science Foundation of China","keywords":"Sonodynamic therapy; Nanocomposite; Calcium; Immunotherapy; Chemistry; Materials science; Medicine; Nanotechnology; Internal medicine; Organic chemistry; Biochemistry; Apoptosis; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343669,0.0002110851,0.0001734105,0.0001909929,0.0001132584,0.0001647847,0.00006640823,0.0001032202,0.000007134361],"category_scores_gemma":[0.000007145422,0.0001944034,0.00004956299,0.0002520533,0.00002985378,0.0009453651,0.00001003408,0.0001180204,0.00001610112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002395413,"about_ca_system_score_gemma":0.00003910265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001401487,"about_ca_topic_score_gemma":0.00002975914,"domain_scores_codex":[0.9991572,0.00001780275,0.0002224397,0.0002333227,0.0001639988,0.000205182],"domain_scores_gemma":[0.9995666,0.00009551146,0.00003862454,0.0001719032,0.00008369268,0.00004363278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003791385,0.00002427406,0.0000161666,0.0001782211,0.0001130199,0.000003834702,0.002580205,0.003155952,0.9546881,0.00157853,0.0002116084,0.03707093],"study_design_scores_gemma":[0.00218424,0.000855691,0.0001903341,0.0003928458,0.00006302469,0.0000187381,0.0002870562,0.3752452,0.5981776,0.006403734,0.0155797,0.0006018012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2822203,0.002250403,0.7126439,0.0003654691,0.0008191583,0.0009608598,0.0000578686,0.0005520994,0.000129972],"genre_scores_gemma":[0.9969692,0.0003342398,0.001723618,0.00004469073,0.0001008913,0.0003321709,0.0001789551,0.0000987315,0.000217494],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7147489,"threshold_uncertainty_score":0.792754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291359222925025,"score_gpt":0.2294565888443692,"score_spread":0.2165429966151189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}