{"id":"W4400065317","doi":"10.1111/ejn.16454","title":"Effect of the mGlu <sub>2</sub> positive allosteric modulator biphenyl‐indanone A as a monotherapy and as adjunct to a low dose of L‐DOPA in the MPTP‐lesioned marmoset","year":2024,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Université de Montréal; Montreal Neurological Institute and Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Parkinson Canada; Weston Brain Institute; Fonds de Recherche du Québec - Santé; Michael J. Fox Foundation for Parkinson's Research; Parkinson Québec","keywords":"MPTP; Parkinsonism; Benserazide; Allosteric modulator; Pharmacology; Chemistry; Medicine; Levodopa; Allosteric regulation; Receptor; Internal medicine; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001886125,0.0004970552,0.000670562,0.0003390861,0.0002834312,0.0003187219,0.0003798298,0.0005427698,0.001666604],"category_scores_gemma":[0.0002006216,0.0002139634,0.0003272472,0.0002077202,0.0004075145,0.0003075885,0.000186704,0.001030327,0.0004867794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003378058,"about_ca_system_score_gemma":0.0004547163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002588454,"about_ca_topic_score_gemma":0.005180802,"domain_scores_codex":[0.9998637,0.00003005395,0.00001484722,0.00001888463,0.00002590427,0.0000465656],"domain_scores_gemma":[0.9998407,0.00001799521,0.00002870947,0.00001275324,0.00001592662,0.00008376301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00696161,0.001327242,0.0003085702,0.00007458936,0.0000464202,0.0002357534,0.0000579091,0.0002151315,0.986963,0.00008109032,0.0001886617,0.003539946],"study_design_scores_gemma":[0.001037746,0.04347,0.006754139,0.00001191995,0.000157857,0.0004716259,0.0001273222,0.002208011,0.9439296,0.00009133648,0.00170894,0.00003154401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985017,0.0003629947,0.0001000956,0.00006741215,0.00003225344,0.00003684663,0.0001841717,0.00004346561,0.0006710405],"genre_scores_gemma":[0.9971455,0.0003665504,0.0006659104,0.00007359518,0.00002226014,0.00006486085,0.0002811879,0.000008852784,0.001371293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002588454,"threshold_uncertainty_score":0.005575359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02062708812543252,"score_gpt":0.3128072873132967,"score_spread":0.2921801991878642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}