{"id":"W4400078934","doi":"10.1016/j.gene.2024.148731","title":"Vascular calcification in chronic kidney disease associated with pathogenic variants in ABCC6","year":2024,"lang":"en","type":"article","venue":"Gene","topic":"Dermatological and Skeletal Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Queen's University; London Health Sciences Centre; Victoria Hospital; McGill University; University of Toronto; Montreal Neurological Institute and Hospital; Western University","funders":"","keywords":"Biology; Kidney disease; Calcification; Kidney; Internal medicine; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006941,0.00009840144,0.00009389169,0.00004549182,0.00001659808,0.00001851608,0.00008890319,0.00008973955,0.00002793043],"category_scores_gemma":[0.00005865557,0.00007886172,0.00005214582,0.0002170025,0.00003901234,0.000003678492,0.00003039337,0.00007210305,0.0000237173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004417624,"about_ca_system_score_gemma":0.0001881503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001027576,"about_ca_topic_score_gemma":0.00009200924,"domain_scores_codex":[0.9992273,0.00006041036,0.0001306089,0.0003007006,0.00008351728,0.0001974169],"domain_scores_gemma":[0.9997068,0.000004455036,0.00001585114,0.0001667814,0.00001367541,0.00009241368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001110588,0.0003283774,0.02517513,0.0001409386,0.0001397064,0.0004158275,0.00007147533,0.001099902,0.9629557,0.0005315802,0.001342088,0.007688256],"study_design_scores_gemma":[0.002801996,0.0003346631,0.9326153,0.0002889262,0.00007511106,0.0000141402,0.00003405496,0.009277582,0.02085133,0.001500222,0.03139164,0.0008150472],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991918,0.006533333,0.0005813345,0.0003110496,0.00005625333,0.0001658239,0.00003999216,0.00001866605,0.0003755342],"genre_scores_gemma":[0.9984882,0.0004381554,0.00002868312,0.0001997645,0.00002621032,0.00004772846,0.0005765273,0.00001242582,0.0001822736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9421043,"threshold_uncertainty_score":0.3215888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006880367326102694,"score_gpt":0.224527379696314,"score_spread":0.2176470123702113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}