{"id":"W4400084799","doi":"10.1210/jendso/bvae121","title":"Genome-wide Methylation Dynamics and Context-dependent Gene Expression Variability in Differentiating Preadipocytes","year":2024,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Agri-Food Biotechnology Institute; Ministry of Electronics and Information technology; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"DNA methylation; Differentially methylated regions; Biology; Epigenetics; Bisulfite sequencing; Adipogenesis; Methylation; Epigenomics; Methylated DNA immunoprecipitation; Genetics; Illumina Methylation Assay; Gene; Gene expression; Promoter; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008957438,0.00008059765,0.0001517684,0.0002937697,0.0001034831,0.0001653031,0.00007919278,0.0001132097,0.0005349393],"category_scores_gemma":[0.0001256442,0.0001121282,0.0001182665,0.0002874306,0.0001053875,0.00006517481,0.0001261823,0.0002070606,0.0001475512],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001359973,"about_ca_system_score_gemma":0.000102761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001890425,"about_ca_topic_score_gemma":0.002821311,"domain_scores_codex":[0.9999347,0.000005078933,0.000003265942,0.00003292137,0.00001432047,0.000009743069],"domain_scores_gemma":[0.9999421,0.00001239695,0.00001615184,0.00000660648,0.00001291604,0.000009977047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001087263,0.000004093351,0.006701147,0.00001573995,0.00001115355,0.00002190521,0.00007488284,0.00009054096,0.9907376,0.00002889269,0.00001880511,0.002186494],"study_design_scores_gemma":[0.000007260614,0.0001372902,0.7970147,0.000004401169,0.00004660446,0.0002653294,0.0001689911,0.001596629,0.1992092,0.0001373754,0.001398991,0.00001317887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996914,0.0006054693,0.001197109,0.00001615421,0.000002241061,0.000006481152,0.0008950018,0.00002474517,0.000338773],"genre_scores_gemma":[0.9958528,0.0004163779,0.001394995,0.0000221638,0.00000257416,0.00002151738,0.001341776,0.00001097135,0.0009367418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001890425,"threshold_uncertainty_score":0.003758848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00741363397478041,"score_gpt":0.2509855280408483,"score_spread":0.2435718940660679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}