{"id":"W4400084799","doi":"10.1210/jendso/bvae121","title":"Genome-wide Methylation Dynamics and Context-dependent Gene Expression Variability in Differentiating Preadipocytes","year":2024,"lang":"en","type":"article","venue":"Journal of the Endocrine Society","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Agri-Food Biotechnology Institute; Ministry of Electronics and Information technology; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"DNA methylation; Differentially methylated regions; Biology; Epigenetics; Bisulfite sequencing; Adipogenesis; Methylation; Epigenomics; Methylated DNA immunoprecipitation; Genetics; Illumina Methylation Assay; Gene; Gene expression; Promoter; Molecular biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007426675,0.0000967915,0.0001344535,0.000021081,0.00005782202,0.00004438487,0.0001171249,0.00006039274,0.000005922153],"category_scores_gemma":[0.0002647638,0.00006585644,0.0001984493,0.00006779282,0.00003417838,0.00001017439,0.0001337838,0.0001969775,1.739192e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006841296,"about_ca_system_score_gemma":0.00004998227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007872667,"about_ca_topic_score_gemma":0.00001552383,"domain_scores_codex":[0.9990601,0.0001703116,0.0003326166,0.0001556438,0.0001609465,0.000120413],"domain_scores_gemma":[0.9994859,0.0001095488,0.0001384172,0.0001581964,0.00006910945,0.00003888985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001974154,0.00003837196,0.0541424,0.00005761493,0.00009943185,0.000001805019,0.0002989513,0.0009057288,0.9360535,0.00003627417,0.00003065468,0.008315598],"study_design_scores_gemma":[0.0005160071,0.0001004518,0.08187763,0.00007042869,0.00007023347,0.00001895329,0.0002126312,0.006429938,0.9075729,0.001736277,0.001264714,0.0001298806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680456,0.009292958,0.0219378,0.0002936852,0.0002700188,0.000104387,0.000008418562,0.000003304041,0.00004382035],"genre_scores_gemma":[0.9965723,0.001571127,0.001508132,0.00003221658,0.0001798943,0.000002480894,0.000009547265,0.00001218069,0.0001121602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02852666,"threshold_uncertainty_score":0.2685547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00741363397478041,"score_gpt":0.2509855280408483,"score_spread":0.2435718940660679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}