{"id":"W4400085192","doi":"10.1161/jaha.123.032419","title":"Monoclonal Antibody chP3R99 Reduces Subendothelial Retention of Atherogenic Lipoproteins in Insulin‐Resistant Rats: Acute Treatment Versus Long‐Term Protection as an Idiotypic Vaccine for Atherosclerosis","year":2024,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Alberta","funders":"","keywords":"Lipoprotein; Insulin resistance; Internal medicine; Endocrinology; Insulin; Apolipoprotein B; Lipoprotein lipase; Low-density lipoprotein; Chemistry; Cholesterol; Medicine; Adipose tissue","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003118199,0.0008857121,0.0006550658,0.0005637212,0.0001841103,0.0002642424,0.0004897282,0.0008600242,0.001547029],"category_scores_gemma":[0.00015387,0.0002549065,0.0004778675,0.0002432707,0.0003244483,0.0002964488,0.0001706191,0.001736447,0.000514648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002476797,"about_ca_system_score_gemma":0.0002946407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004909486,"about_ca_topic_score_gemma":0.0005064423,"domain_scores_codex":[0.9997839,0.00002648335,0.00001884456,0.0000348633,0.00003701497,0.00009880972],"domain_scores_gemma":[0.999645,0.00003825945,0.0001020293,0.00003773244,0.00004660992,0.0001303942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001307603,0.0009309049,0.0001344464,0.00004832324,0.0000139575,0.00004978274,0.00001385023,0.00004801125,0.9955463,0.00004191631,0.00006151435,0.00180327],"study_design_scores_gemma":[0.0003588498,0.01210466,0.003233573,0.00001167866,0.00007236274,0.0002035664,0.00002473892,0.0006017603,0.9823685,0.00003408983,0.0009759113,0.00001024315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967315,0.0006889391,0.001231816,0.0001336641,0.00006846136,0.00004890712,0.0002168838,0.0002205435,0.0006592826],"genre_scores_gemma":[0.9917127,0.001084814,0.002320362,0.0001447343,0.00006674483,0.0001256594,0.0006954033,0.00004970638,0.003799859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001547029,"threshold_uncertainty_score":0.005175352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02112117820394224,"score_gpt":0.293398076414558,"score_spread":0.2722768982106158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}