{"id":"W4400086973","doi":"10.1097/pas.0000000000002272","title":"A Comprehensive Clinicopathologic and Molecular Reappraisal of GLI1-altered Mesenchymal Tumors with Pooled Outcome Analysis Showing Poor Survival in GLI1- amplified Versus GLI1-rearranged Tumors","year":2024,"lang":"en","type":"article","venue":"The American Journal of Surgical Pathology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute","keywords":"GLI1; Biology; Malignancy; Gene duplication; Pathology; Cancer research; Medicine; Gene; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005769826,0.0003234485,0.0004618418,0.001886765,0.0002782479,0.0003624499,0.0001494044,0.0001276927,0.001066657],"category_scores_gemma":[0.0008788087,0.0001102144,0.0003898178,0.0008955938,0.0001858431,0.0002757256,0.0005668806,0.0001831712,0.0002566705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001809178,"about_ca_system_score_gemma":0.0001829485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005823075,"about_ca_topic_score_gemma":0.0008993745,"domain_scores_codex":[0.9997632,0.00004500616,0.00003213453,0.00006558444,0.00004715746,0.0000468152],"domain_scores_gemma":[0.9995288,0.0001082273,0.0001349117,0.00006624979,0.00006573229,0.00009612161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006206199,0.00001399115,0.9798483,0.0000240637,0.0001585866,0.0007486936,0.0000737883,0.0003058245,0.008101591,0.00002689019,0.000158773,0.009918829],"study_design_scores_gemma":[0.000004675439,0.0001417778,0.9959686,0.000003496916,0.0001440845,0.002165631,0.00007891693,0.0004511256,0.0006758422,0.00004837321,0.0003107233,0.000006839856],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977013,0.0004128049,0.0008328155,0.00001701565,0.000002973559,0.000009959248,0.0004421645,0.00002998449,0.0005509548],"genre_scores_gemma":[0.9989952,0.00008548729,0.0002274948,0.000007403718,0.000008754865,0.000007641419,0.0005555594,0.000007613413,0.0001048341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001886765,"threshold_uncertainty_score":0.003568292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03883934445876823,"score_gpt":0.3311412415047469,"score_spread":0.2923018970459787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}