{"id":"W4400087312","doi":"10.1016/j.tetlet.2024.155162","title":"Exploring macrocyclization strategies to design novel octreotate-based radioconjugates","year":2024,"lang":"en","type":"article","venue":"Tetrahedron Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"TRIUMF","funders":"","keywords":"Chemistry; Somatostatin receptor 2; Regioselectivity; Somatostatin receptor; Somatostatin; Cysteine; In vivo; Combinatorial chemistry; Peptide; Stereochemistry; Receptor; Biochemistry; Internal medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319155,0.0003893725,0.0001846069,0.0001809654,0.00009341358,0.000244653,0.0001543376,0.0002146066,0.0007928525],"category_scores_gemma":[0.0001840074,0.0001244788,0.0001795602,0.0001502997,0.0001501622,0.0002351892,0.0002144739,0.0002926898,0.0003607174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479959,"about_ca_system_score_gemma":0.0001822726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002455658,"about_ca_topic_score_gemma":0.0005564722,"domain_scores_codex":[0.999907,0.00001406685,0.000009451578,0.0000239437,0.00001783287,0.00002761915],"domain_scores_gemma":[0.9999255,0.00001175518,0.00002901317,0.00000787737,0.00001011586,0.00001581587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006757351,0.00002199432,0.0001114307,0.00004613548,0.000006813373,0.00008239361,0.00002773444,0.0009530892,0.9937506,0.0004442337,0.00004478509,0.004443075],"study_design_scores_gemma":[0.00001586051,0.0005792138,0.0005088525,0.000004994378,0.00001295672,0.0001236646,0.00001617538,0.001045418,0.9931142,0.00007318798,0.004496938,0.000008685946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747511,0.002103555,0.01875317,0.0001060814,0.00005117785,0.0001805788,0.0002091722,0.0001556575,0.003689547],"genre_scores_gemma":[0.9804476,0.001700599,0.01516976,0.00009434907,0.00001493558,0.0001199808,0.0002111358,0.00003815619,0.002203515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007928525,"threshold_uncertainty_score":0.002652407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06213578128050053,"score_gpt":0.262689165751311,"score_spread":0.2005533844708105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}