{"id":"W4400105048","doi":"10.1021/acs.jnatprod.3c01234","title":"Discovery of the Lipopeptides Albubactins A–H from <i>Streptomyces albidoflavus</i> RKJM0023 via Chemical Elicitation with Rhamnolipids and Synthesis of Albubactin A","year":2024,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Fondation Jean-Louis Lévesque","keywords":"Streptomycetaceae; Streptomyces; Chemical synthesis; Chemistry; Actinomycetales; Stereochemistry; Organic chemistry; Bacteria; Biochemistry; Microbiology; Combinatorial chemistry; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003826641,0.000234043,0.0006001099,0.0001613211,0.0000433767,0.00005319032,0.0001996233,0.0001105043,0.00001127754],"category_scores_gemma":[0.001526486,0.0001134179,0.0001888903,0.0005410022,0.0002840035,0.0005329423,0.00007303249,0.0005950799,0.000001345529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005612022,"about_ca_system_score_gemma":0.0002049904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001338669,"about_ca_topic_score_gemma":0.0000107571,"domain_scores_codex":[0.9982253,0.00008177396,0.0006685088,0.0003238034,0.000510028,0.0001905869],"domain_scores_gemma":[0.9980583,0.0004973832,0.0005841375,0.0003055848,0.0004970144,0.00005758175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008359817,0.0001373646,0.0004788633,0.0004996244,0.0004272819,0.0000168372,0.0003073949,0.000001235863,0.9689648,0.00001999499,0.002081477,0.02622913],"study_design_scores_gemma":[0.0004044738,0.000233126,0.004595168,0.002072554,0.0006179297,0.0004471402,0.0001622112,0.00003666416,0.9896406,0.00009162193,0.001558902,0.0001396069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815689,0.006878699,0.000004494064,0.01049022,0.0006684727,0.0002600884,0.00003068876,0.00001258138,0.00008586075],"genre_scores_gemma":[0.9964455,0.0003991866,0.001806218,0.0001106563,0.0009565584,5.39825e-7,0.000004073827,0.00002781461,0.0002494399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02608952,"threshold_uncertainty_score":0.4625047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006343920742307878,"score_gpt":0.2203399388386288,"score_spread":0.2139960180963209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}