{"id":"W4400105048","doi":"10.1021/acs.jnatprod.3c01234","title":"Discovery of the Lipopeptides Albubactins A–H from <i>Streptomyces albidoflavus</i> RKJM0023 via Chemical Elicitation with Rhamnolipids and Synthesis of Albubactin A","year":2024,"lang":"en","type":"article","venue":"Journal of Natural Products","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Fondation Jean-Louis Lévesque","keywords":"Streptomycetaceae; Streptomyces; Chemical synthesis; Chemistry; Actinomycetales; Stereochemistry; Organic chemistry; Bacteria; Biochemistry; Microbiology; Combinatorial chemistry; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000881973,0.000357864,0.0002081663,0.0001936905,0.000111561,0.0002034667,0.0001147294,0.0001499532,0.0004285237],"category_scores_gemma":[0.00009755387,0.00007500163,0.0001981334,0.0002428026,0.0001040359,0.0001164638,0.0001778021,0.0002964541,0.000224893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001484832,"about_ca_system_score_gemma":0.000196688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004470868,"about_ca_topic_score_gemma":0.0007994804,"domain_scores_codex":[0.9999365,0.00001230558,0.000007152484,0.0000103828,0.0000205372,0.00001314281],"domain_scores_gemma":[0.9999352,0.000008892676,0.0000181149,0.000005871722,0.00001028242,0.00002171352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003978008,0.000006607341,0.0001131843,0.00001285622,0.000001549905,0.0000435112,0.000003245346,0.00003954809,0.9991591,0.00001185972,0.000006204104,0.0005624625],"study_design_scores_gemma":[0.00001489356,0.0003523065,0.007569332,0.000005172285,0.0000174759,0.0002228736,0.00003960469,0.0005236609,0.9898432,0.00003299673,0.00137324,0.000005218999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950596,0.0003993149,0.002452954,0.0000437374,0.000007773324,0.00004909548,0.0007275818,0.00003857405,0.001221316],"genre_scores_gemma":[0.9909539,0.000418513,0.005487157,0.00003157962,0.000006275809,0.00003312372,0.001805131,0.00001237094,0.001251939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004470868,"threshold_uncertainty_score":0.001433551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006343920742307878,"score_gpt":0.2203399388386288,"score_spread":0.2139960180963209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}