{"id":"W4400105341","doi":"10.1101/2024.06.23.600249","title":"A selective alternative pathway complement inhibitor for treatment of paroxysmal nocturnal hemoglobinuria","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Deutsches Elektronen-Synchrotron; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Univerzita Karlova v Praze","keywords":"Paroxysmal nocturnal hemoglobinuria; Eculizumab; Complement system; Alternative complement pathway; Immunology; Hemolysis; Immune system; CD59; Lectin pathway; Classical complement pathway; Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003622602,0.0008351011,0.00124027,0.0003661029,0.0001840955,0.00008404488,0.0005228192,0.0004530313,0.0002382783],"category_scores_gemma":[0.00009194726,0.0007718863,0.0005807639,0.0002520452,0.0002114874,0.00005092123,0.0005910426,0.000327843,0.0001395495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001088972,"about_ca_system_score_gemma":0.001080762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001693329,"about_ca_topic_score_gemma":0.00001548374,"domain_scores_codex":[0.9964184,0.0003140535,0.001120539,0.001242605,0.0001545917,0.0007497659],"domain_scores_gemma":[0.9972134,0.0002541882,0.0007984494,0.0009472515,0.0006789007,0.0001078028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005060168,0.0009246831,0.002377709,0.001134472,0.003210866,0.00002597963,0.000131752,0.00004640564,0.9859914,0.002537169,0.003103206,0.0000103804],"study_design_scores_gemma":[0.003156275,0.00101569,0.005878315,0.000922127,0.0005965416,8.842603e-8,0.00002418414,0.0000716843,0.9569192,0.00005601663,0.0305772,0.0007826845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676415,0.009428733,0.0007176757,0.0001907987,0.005802767,0.004448067,0.01141699,0.0003329602,0.00002055916],"genre_scores_gemma":[0.9961917,0.00006659391,0.0009371014,0.00003472917,0.0005855411,0.001998696,0.00001722231,0.0001313136,0.00003712309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02907217,"threshold_uncertainty_score":0.9994732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02291930855005402,"score_gpt":0.256232083571346,"score_spread":0.233312775021292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}