{"id":"W4400105341","doi":"10.1101/2024.06.23.600249","title":"A selective alternative pathway complement inhibitor for treatment of paroxysmal nocturnal hemoglobinuria","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"Deutsches Elektronen-Synchrotron; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; Univerzita Karlova v Praze","keywords":"Paroxysmal nocturnal hemoglobinuria; Eculizumab; Complement system; Alternative complement pathway; Immunology; Hemolysis; Immune system; CD59; Lectin pathway; Classical complement pathway; Biology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001203631,0.0001680985,0.0002260782,0.0001443895,0.00009919576,0.0001194752,0.0001635313,0.0002393687,0.001224605],"category_scores_gemma":[0.00006318923,0.00003728347,0.0001429377,0.00007240001,0.00008780006,0.00006029852,0.00007768346,0.0004360606,0.0002667666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000139676,"about_ca_system_score_gemma":0.0001813356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003818765,"about_ca_topic_score_gemma":0.0006058401,"domain_scores_codex":[0.9999728,0.000005379248,0.000002022475,0.000003606435,0.000008806471,0.00000740416],"domain_scores_gemma":[0.9999837,0.000003093147,0.000003207056,0.000001471589,0.000002711264,0.000005836098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006176769,0.001576318,0.001356797,0.0005190994,0.00017441,0.001579295,0.00006452437,0.0006647125,0.7809893,0.001216548,0.00674794,0.1989343],"study_design_scores_gemma":[0.005171961,0.01550418,0.01694564,0.00007562072,0.0003451595,0.006912716,0.00005282269,0.00485241,0.8671945,0.0004431001,0.08247406,0.00002779125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9513238,0.03168293,0.006733772,0.001323198,0.0005364888,0.0002995456,0.0005438283,0.0003445658,0.007211717],"genre_scores_gemma":[0.9868553,0.004729473,0.002921016,0.0002524802,0.0001036047,0.00007271265,0.0005416434,0.00001370467,0.004509992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224605,"threshold_uncertainty_score":0.004096746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02291930855005402,"score_gpt":0.256232083571346,"score_spread":0.233312775021292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}