{"id":"W4400109975","doi":"10.1016/j.celrep.2024.114414","title":"Retinoic acid enhances HIV-1 reverse transcription and transcription in macrophages via mTOR-modulated mechanisms","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal Clinical Research Institute; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; National Institutes of Health; Fonds de Recherche du Québec - Santé; Fonds De La Recherche Scientifique - FNRS; Université Laval; Fonds de recherche du Québec; Canadian Institutes of Health Research; International Association of Sedimentologists; McGill University; McGill University Health Centre; National Institute of Diabetes and Digestive and Kidney Diseases; ViiV Healthcare; Thomas Jefferson University; Koning Boudewijnstichting; Fondation du CHUM; Canadian Foundation for AIDS Research","keywords":"Retinoic acid; SAMHD1; Biology; Transcription (linguistics); PI3K/AKT/mTOR pathway; Viral replication; Cell biology; Gene knockdown; Transcription factor; Transcriptome; RNA polymerase II; Reverse transcriptase; Virology; RNA; Gene expression; Gene; Signal transduction; Virus; Genetics; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001742387,0.0001367897,0.0001528227,0.0002878376,0.0001639527,0.0003195044,0.00008127924,0.0001205648,0.001369411],"category_scores_gemma":[0.0001113468,0.00009152629,0.0002219607,0.0001345884,0.0001771784,0.000116786,0.0001743501,0.0002351869,0.0003883653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001445929,"about_ca_system_score_gemma":0.0001949293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003492218,"about_ca_topic_score_gemma":0.0009673398,"domain_scores_codex":[0.9998531,0.00004021858,0.00001058128,0.00002844541,0.00003293277,0.00003464117],"domain_scores_gemma":[0.9999388,0.00001171958,0.00001913707,0.000008238527,0.00001011057,0.00001184229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001423062,0.00001416911,0.0007134267,0.00003021086,0.000006460309,0.00003853639,0.00001740248,0.00003866962,0.9968498,0.00008812634,0.00003785848,0.00202294],"study_design_scores_gemma":[0.00002486795,0.0004201884,0.03281036,0.00001812802,0.000035811,0.000449041,0.0001244733,0.0009483607,0.961165,0.0001844102,0.003811938,0.000007347572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911882,0.00354788,0.001721888,0.0001483659,0.00002313542,0.00002223981,0.0005048437,0.00007685977,0.002766538],"genre_scores_gemma":[0.9939522,0.001398244,0.002072016,0.00007052882,0.0000167188,0.00002445805,0.0003769608,0.00001236936,0.002076338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369411,"threshold_uncertainty_score":0.004581153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00870008331873948,"score_gpt":0.2315785233114754,"score_spread":0.2228784399927359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}