{"id":"W4400119758","doi":"10.1128/mbio.01038-24","title":"Molecular insights into type I interferon suppression and enhanced pathogenicity by species B human adenoviruses B7 and B14","year":2024,"lang":"en","type":"article","venue":"mBio","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Pathogenicity; Interferon; Virology; Biology; Microbiology; Interferon type I; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001496394,0.0002974507,0.0001431154,0.0002787114,0.0001222737,0.0002660456,0.0001461294,0.0002985727,0.0007146656],"category_scores_gemma":[0.00007520782,0.0000983733,0.0002946533,0.0001037027,0.0001699928,0.0002556089,0.0001507465,0.0002916141,0.0001858017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001837257,"about_ca_system_score_gemma":0.0001881573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003991026,"about_ca_topic_score_gemma":0.0003935884,"domain_scores_codex":[0.9999105,0.00002074659,0.000009513928,0.00001574219,0.00002587168,0.00001763156],"domain_scores_gemma":[0.9999083,0.00001319883,0.00002797208,0.000007898583,0.00001849969,0.00002412795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008272644,0.0000227442,0.0006798318,0.0000417845,0.000005718575,0.00007832726,0.00001138913,0.00002454604,0.9974663,0.0001810266,0.00002810951,0.00137737],"study_design_scores_gemma":[0.00005720827,0.001059951,0.0477155,0.00002944593,0.00005175063,0.001418438,0.0003169074,0.003686308,0.938158,0.0005546288,0.00692991,0.00002185291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931974,0.003098294,0.002206113,0.0001182925,0.00002929391,0.00001413277,0.00009977951,0.00002721825,0.001209408],"genre_scores_gemma":[0.994247,0.001908163,0.002358408,0.0001259601,0.00001929324,0.00001120087,0.0002244926,0.000008931475,0.001096619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007146656,"threshold_uncertainty_score":0.002390802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01348839347889138,"score_gpt":0.2956815396102508,"score_spread":0.2821931461313595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}