{"id":"W4400134955","doi":"10.1101/2024.06.22.600196","title":"Nanoparticles co-delivering siRNA and mRNA for simultaneous restoration and silencing of gene/protein expression <i>in vitro</i> and <i>in vivo</i>","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; National Research Council Canada; Ottawa Hospital; Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Institutes of Health Research; University of Ottawa","keywords":"Gene silencing; In vivo; Small interfering RNA; Messenger RNA; RNA interference; In vitro; microRNA; Gene expression; RNA; Luciferase; Cell biology; Biology; Chemistry; Molecular biology; Cancer research; Gene; Transfection; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820461,0.0003055263,0.0001937958,0.0001681422,0.0001332564,0.0001989842,0.0001557453,0.000314845,0.001024391],"category_scores_gemma":[0.0001144732,0.0001316327,0.0001972766,0.0000937264,0.0001917154,0.0001488561,0.0001549262,0.0002737501,0.0004412961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000273281,"about_ca_system_score_gemma":0.0002133486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001048799,"about_ca_topic_score_gemma":0.001047465,"domain_scores_codex":[0.9998747,0.00001750591,0.000008931634,0.00003797025,0.00004377987,0.00001711636],"domain_scores_gemma":[0.9999489,0.00001196119,0.00001542057,0.000004735499,0.0000104069,0.000008724364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002025619,0.000009092676,0.00002281419,0.00001791249,0.000001968072,0.00001708863,0.000005312043,0.00008568871,0.999175,0.00006362994,0.00006773927,0.0005134034],"study_design_scores_gemma":[0.000003382454,0.00003925548,0.0001079172,0.000001037909,0.000003285385,0.00002621168,0.000002252199,0.001042168,0.9981874,0.000009140816,0.0005763626,0.000001547779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573687,0.002095372,0.03269784,0.000229661,0.0001950394,0.00008779695,0.0002877038,0.000432789,0.006605121],"genre_scores_gemma":[0.9739382,0.0005334698,0.01552568,0.00008868517,0.00002112327,0.00006556194,0.0002486971,0.0001081276,0.009470416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001048799,"threshold_uncertainty_score":0.003426969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009039451592336245,"score_gpt":0.2226881634089209,"score_spread":0.2136487118165847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}