{"id":"W4400136234","doi":"10.3389/jpps.2024.13040","title":"The role of branched-chain amino acids and their downstream metabolites in mediating insulin resistance","year":2024,"lang":"en","type":"review","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; Memorial University of Newfoundland; University of Alberta; Université de Montréal; Diabetes Canada","funders":"Fonds de Recherche du Québec - Santé; Diabète Québec","keywords":"Insulin resistance; Insulin; Biology; Insulin sensitivity; Endocrinology; Amino acid; Homeostasis; Internal medicine; Obesity; Diabetes mellitus; Metabolism; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000409023,0.0006610095,0.0008839975,0.001817241,0.0002515648,0.001038694,0.0006629855,0.0008884252,0.002650994],"category_scores_gemma":[0.000542499,0.0002197909,0.0004262603,0.001602936,0.0003349673,0.0008762447,0.0006225291,0.001260983,0.001706556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004527837,"about_ca_system_score_gemma":0.001038506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044555,"about_ca_topic_score_gemma":0.001636561,"domain_scores_codex":[0.9998844,0.00002048658,0.00001717377,0.00002298858,0.0000376752,0.00001726239],"domain_scores_gemma":[0.9998246,0.0000704689,0.00002632934,0.000006060746,0.00005201476,0.0000206139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001478153,0.00008762459,0.0003856332,0.02132777,0.0001755561,0.0003682418,0.00006789403,0.0004467974,0.005581968,0.005243438,0.01773755,0.9484298],"study_design_scores_gemma":[0.000018653,0.0001336491,0.001763469,0.003995587,0.0002208914,0.001413785,0.00008132769,0.0001666891,0.00256746,0.003085637,0.9865234,0.00002933898],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002887929,0.9981426,0.000211671,0.0002595209,0.0001379502,0.000003558024,0.00003011484,0.000009552326,0.0009162345],"genre_scores_gemma":[0.001137258,0.9980399,0.0002188292,0.00009690525,0.00007062409,0.000005636873,0.00002805452,0.000001507137,0.0004013345],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002650994,"threshold_uncertainty_score":0.008868515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03909232053902308,"score_gpt":0.3806731019392159,"score_spread":0.3415807814001928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}