{"id":"W4400139045","doi":"10.1016/j.isci.2024.110390","title":"HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralizing antibodies","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Dental and Craniofacial Research; U.S. Public Health Service; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs; Universiteit Antwerpen; Canada Excellence Research Chairs, Government of Canada; National Institute of Allergy and Infectious Diseases; Icahn School of Medicine at Mount Sinai","keywords":"Infectivity; Glycan; Lectin; Microbiology; Antibody; Bacteria; Biology; Virology; Fimbria; Virus; Escherichia coli; Glycoprotein; Immunology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001732539,0.0001017746,0.0001080386,0.0001088078,0.0002641532,0.0001674277,0.00009255373,0.00003597581,0.000113983],"category_scores_gemma":[0.00001918694,0.00007235563,0.00001486172,0.0002309992,0.0002490362,0.0004617504,0.00004349802,0.0001331212,0.0003503673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004863161,"about_ca_system_score_gemma":0.00005366798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001603522,"about_ca_topic_score_gemma":0.002147982,"domain_scores_codex":[0.9991242,0.00009553587,0.00008283176,0.0003844202,0.00004197123,0.0002710949],"domain_scores_gemma":[0.9996875,0.00009892407,0.00001747365,0.0001295108,0.00002664672,0.00003994274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003292468,0.00005150348,0.001870649,0.00001384983,0.00002018732,0.00002598691,0.001202979,0.000001327894,0.9823308,0.0003683803,0.001035399,0.01274972],"study_design_scores_gemma":[0.0003818719,0.000990412,0.06170606,0.000185395,0.00001053838,0.0000991734,0.0003363307,0.000003578472,0.7491984,0.0001157556,0.1867471,0.0002253828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951978,0.002026275,0.0005363075,0.0003305782,0.0005406392,0.0001466321,0.00003216083,0.00007191987,0.001117675],"genre_scores_gemma":[0.9983273,0.0001995259,0.0002658421,0.00001639965,0.00003575756,0.00002176351,0.00001545529,0.000005689745,0.001112239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2331324,"threshold_uncertainty_score":0.450338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215167934745087,"score_gpt":0.3027944695329722,"score_spread":0.2806427901855213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}