{"id":"W4400139045","doi":"10.1016/j.isci.2024.110390","title":"HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and resistance to neutralizing antibodies","year":2024,"lang":"en","type":"article","venue":"iScience","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Dental and Craniofacial Research; U.S. Public Health Service; National Cancer Institute; National Institutes of Health; U.S. Department of Veterans Affairs; Universiteit Antwerpen; Canada Excellence Research Chairs, Government of Canada; National Institute of Allergy and Infectious Diseases; Icahn School of Medicine at Mount Sinai","keywords":"Infectivity; Glycan; Lectin; Microbiology; Antibody; Bacteria; Biology; Virology; Fimbria; Virus; Escherichia coli; Glycoprotein; Immunology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852229,0.0002540924,0.0002205574,0.0001419722,0.0001228273,0.0002848496,0.0001669596,0.0003332928,0.001135139],"category_scores_gemma":[0.0001639394,0.0001057197,0.0002184632,0.00008033338,0.000130104,0.0001387685,0.000189195,0.0006182413,0.0001796203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002449894,"about_ca_system_score_gemma":0.0001507605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003759651,"about_ca_topic_score_gemma":0.0006208015,"domain_scores_codex":[0.9998012,0.0000605259,0.000007504123,0.00001847554,0.00004320776,0.00006897545],"domain_scores_gemma":[0.9999356,0.00002108475,0.000007717427,0.000007449788,0.000009950207,0.00001818543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000111975,0.0001095452,0.0001565064,0.00001788485,0.000005763774,0.00001517351,0.000009999328,0.00004546905,0.9980271,0.0000404686,0.0000337675,0.001426419],"study_design_scores_gemma":[0.00002860129,0.00211134,0.007247202,0.000009904327,0.00002364482,0.0002655128,0.00003808343,0.001644271,0.986653,0.000054202,0.001917147,0.000007020153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974549,0.0007536993,0.0005578194,0.00004276315,0.00001744124,0.00001362151,0.00002521499,0.00002090703,0.001113588],"genre_scores_gemma":[0.9968009,0.0003877108,0.00110878,0.00005112724,0.00001100442,0.00001190977,0.00007646979,0.000005022983,0.001546955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001135139,"threshold_uncertainty_score":0.003797412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02215167934745087,"score_gpt":0.3027944695329722,"score_spread":0.2806427901855213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}