{"id":"W4400143961","doi":"10.1016/j.annonc.2024.05.021","title":"10P A placebo-controlled study comparing doses and efficacy of lentinula edodes mycelia for chemotherapy-induced peripheral neuropathy in colorectal cancer: The LEMON trial","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Sanofi Genzyme; Genentech; Foundation Medicine; Sierra Oncology; INCLIVA Instituto de Investigación Sanitaria; European Society for Medical Oncology; PharmaMar; Daiichi Sankyo Europe; Gilead Sciences; Servier; FibroGen; Astellas Pharma; Eisai; Natera; F-star Therapeutics; Ribon Therapeutics; Ipsen; Sociedad Española de Oncología Médica; BeiGene; Clovis Oncology; Merck KGaA; Sanofi; Amgen; Pfizer; Les Laboratories Pierre Fabre; AstraZeneca; Eli Lilly and Company","keywords":"Medicine; Lentinula; Placebo; Chemotherapy; Colorectal cancer; Peripheral neuropathy; Cancer; Internal medicine; Oncology; Chemotherapy-induced peripheral neuropathy; Food science; Pathology; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001226618,0.001626593,0.002985126,0.0004225491,0.0004236394,0.001034959,0.0009186442,0.002486984,0.01162295],"category_scores_gemma":[0.0014591,0.0005618283,0.002265718,0.000338903,0.001092835,0.0009285384,0.000419082,0.00372318,0.001629237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000746056,"about_ca_system_score_gemma":0.0007268771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009639467,"about_ca_topic_score_gemma":0.001867403,"domain_scores_codex":[0.9994534,0.0002826791,0.00002835778,0.0001128819,0.00003160189,0.00009111422],"domain_scores_gemma":[0.9992846,0.0002450245,0.0001364556,0.00006747543,0.00004371503,0.0002228883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9852065,0.00382211,0.0001690661,0.0004607105,0.0006346676,0.00002372213,0.0000131979,0.00008038566,0.00186011,0.00005269679,0.0004219641,0.007254757],"study_design_scores_gemma":[0.9140337,0.08317827,0.001072139,0.00005449985,0.0005410999,0.00001907242,0.00001815024,0.0001515897,0.0003614857,0.00009646718,0.0004600311,0.00001347539],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782445,0.009509787,0.0007538542,0.001499999,0.001141014,0.002741511,0.001669078,0.0002294521,0.004210865],"genre_scores_gemma":[0.983156,0.003255063,0.0008177147,0.001908961,0.0005497662,0.001808144,0.001101238,0.00002835655,0.007374777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01162295,"threshold_uncertainty_score":0.03888267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1037315914267791,"score_gpt":0.4469295965515289,"score_spread":0.3431980051247498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}