{"id":"W4400149699","doi":"10.1016/j.cdnut.2024.102658","title":"Distinct Mechanisms of Action of Phytoestrogens in SIRT1-Mediated Effects on DNA Methylation and Silencing of Aging-Related Genes in Mammary Epithelial Cells","year":2024,"lang":"en","type":"article","venue":"Current Developments in Nutrition","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"DNA methylation; Phytoestrogens; Gene silencing; Gene; Biology; Methylation; DNA; Cell biology; Genetics; Gene expression; Estrogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000285571,0.0002889239,0.0003847041,0.0002677773,0.0001584894,0.0003576712,0.0002627914,0.000352797,0.001388384],"category_scores_gemma":[0.0001276532,0.0001865939,0.0006670678,0.000144133,0.0002888426,0.0003184395,0.0002504003,0.0004228653,0.0002777035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003755173,"about_ca_system_score_gemma":0.0002587906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001210382,"about_ca_topic_score_gemma":0.003619009,"domain_scores_codex":[0.9998378,0.00003088674,0.00001317356,0.00003931532,0.00003390166,0.00004491578],"domain_scores_gemma":[0.9999118,0.00001388072,0.00002111247,0.00001401691,0.00002271155,0.00001644426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005433017,0.00003715102,0.0007299932,0.0001080017,0.00004573477,0.00006324865,0.00005521282,0.00006527032,0.9936064,0.0005710572,0.00007843719,0.004096133],"study_design_scores_gemma":[0.00008743352,0.0008376133,0.06055021,0.00003743473,0.0002242253,0.0003753824,0.0002437692,0.0009582476,0.9276043,0.0005277907,0.008529844,0.000023648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.95539,0.03332333,0.005686281,0.0005263647,0.0001189449,0.0000449992,0.0008940573,0.0001473273,0.003868764],"genre_scores_gemma":[0.9888082,0.005810337,0.001148772,0.0001826333,0.00002205578,0.00002298647,0.0005210113,0.0000152998,0.003468716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001388384,"threshold_uncertainty_score":0.004644573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01784306035241997,"score_gpt":0.2929134332039965,"score_spread":0.2750703728515765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}