{"id":"W4400179293","doi":"10.62497/irabcs.2024.37","title":"Targeting protein-protein interactions for therapeutic intervention in Parkinson's disease to delay progression.","year":2024,"lang":"en","type":"article","venue":"Innovative Research in Applied Biological and Chemical Sciences","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Parkinson's disease; Adverse effect; Disease; Internal medicine; Intervention (counseling); Montreal Cognitive Assessment; Motor symptoms; Physical therapy; Therapeutic effect; Cognitive impairment; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001253509,0.0001071465,0.0001088594,0.000138083,0.0001299952,0.00006585555,0.0001663424,0.0001082363,0.000009792332],"category_scores_gemma":[0.0002048654,0.00006311665,0.00002825637,0.001100932,0.0006113381,0.000005225804,0.0002608816,0.0002910406,0.000003562959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002834123,"about_ca_system_score_gemma":0.00004112094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004574929,"about_ca_topic_score_gemma":0.000003018861,"domain_scores_codex":[0.9986528,0.00008093954,0.0002173887,0.0005319684,0.0001505783,0.0003663715],"domain_scores_gemma":[0.9997036,0.00007693819,0.000020884,0.00005338834,0.00007223697,0.00007293471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002464983,0.0001156436,0.001292278,0.00004533053,0.00001102921,0.000003935369,0.00003645659,0.000002065683,0.9262893,0.004549112,0.00008703,0.06732136],"study_design_scores_gemma":[0.0008321951,0.00133053,0.004041892,0.00104164,0.000002734156,0.00000337017,0.00125177,0.0008465361,0.8353067,0.04492112,0.1098808,0.0005406911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917115,0.002921201,0.0006588087,0.002910454,0.00003564885,0.001062399,0.0000105565,0.00001182358,0.0006776346],"genre_scores_gemma":[0.9977549,0.00009977422,0.001094953,0.00005173654,0.00008046997,0.0008432816,0.00002017089,0.000004252825,0.00005050758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1097938,"threshold_uncertainty_score":0.2573822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08110367397421829,"score_gpt":0.4189610437179439,"score_spread":0.3378573697437256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}