{"id":"W4400188764","doi":"10.1371/journal.ppat.1012350","title":"Norwegian moose CWD induces clinical disease and neuroinvasion in gene-targeted mice expressing cervid S138N prion protein","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Food Inspection Agency; Genome Canada; Canadian Wildlife Health Cooperative; University of Alberta; Parks Canada; University of Calgary","keywords":"Chronic wasting disease; Biology; Prion protein; Spleen; Scrapie; Virology; Lymphatic system; Transmissible spongiform encephalopathy; Disease; Transgene; Gene; Immunology; Pathology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002668947,0.0002118444,0.0001811943,0.00008553771,0.00009620764,0.0001118009,0.0001592596,0.0001670496,0.00002125373],"category_scores_gemma":[0.000315293,0.0002010567,0.0001272228,0.0001390702,0.00006562001,0.00001650517,0.000232303,0.0002060738,0.00001237823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001460163,"about_ca_system_score_gemma":0.0001525634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006322515,"about_ca_topic_score_gemma":0.000005114763,"domain_scores_codex":[0.9982435,0.0002361247,0.0003548823,0.0007000102,0.0001663789,0.0002991528],"domain_scores_gemma":[0.9992482,0.00002945421,0.00006461078,0.0003271963,0.00003665062,0.0002938579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001404476,0.0001220339,0.005711184,0.0001748367,0.00002905563,0.0001576037,0.00005289607,0.00001030209,0.9672114,0.000009768609,0.00005731742,0.02632321],"study_design_scores_gemma":[0.001134952,0.0004202827,0.06844216,0.001024321,0.0001756867,0.00002067473,0.00008768836,0.002956457,0.9185945,0.0004734933,0.005776316,0.0008934506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765178,0.02227837,0.00009894397,0.000276423,0.0001228901,0.0005350127,0.00009824349,0.00004503122,0.00002729072],"genre_scores_gemma":[0.9954978,0.00272432,0.0009148551,0.0001984196,0.0003686926,0.00007356245,0.0001280345,0.00004508219,0.00004921759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06273097,"threshold_uncertainty_score":0.8198852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02997102207904501,"score_gpt":0.2867668724241957,"score_spread":0.2567958503451507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}