{"id":"W4400188764","doi":"10.1371/journal.ppat.1012350","title":"Norwegian moose CWD induces clinical disease and neuroinvasion in gene-targeted mice expressing cervid S138N prion protein","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"Alberta Prion Research Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Food Inspection Agency; Genome Canada; Canadian Wildlife Health Cooperative; University of Alberta; Parks Canada; University of Calgary","keywords":"Chronic wasting disease; Biology; Prion protein; Spleen; Scrapie; Virology; Lymphatic system; Transmissible spongiform encephalopathy; Disease; Transgene; Gene; Immunology; Pathology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001229022,0.0005381648,0.0001929135,0.0003614605,0.0001544401,0.0002514178,0.0001866362,0.0003727459,0.0007870964],"category_scores_gemma":[0.0001330319,0.0002304654,0.0002518136,0.0001091687,0.0002781391,0.0001847886,0.0002096273,0.0007803871,0.0002259304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003366471,"about_ca_system_score_gemma":0.0002121231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002288641,"about_ca_topic_score_gemma":0.003940773,"domain_scores_codex":[0.9998146,0.00002212762,0.00001941107,0.00004877965,0.00004205846,0.00005306486],"domain_scores_gemma":[0.9997506,0.00003703923,0.00006892474,0.00002554392,0.00002208434,0.00009592679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002383141,0.000118655,0.0006523604,0.00002125825,0.000007691639,0.0001459435,0.00006765156,0.00005121277,0.9982267,0.00007722875,0.00003168661,0.0003612116],"study_design_scores_gemma":[0.000126522,0.005818043,0.04494696,0.00004022323,0.00006576191,0.001823014,0.000367994,0.002173895,0.9419422,0.0001511929,0.0025233,0.00002084399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999019,0.0001079239,0.0002150825,0.00002251692,0.000006979648,0.00001319507,0.0001313416,0.00001872283,0.0004652176],"genre_scores_gemma":[0.9958959,0.0002439625,0.0005913601,0.00004482655,0.000004886371,0.00003339576,0.0003634616,0.00001451633,0.002807771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002288641,"threshold_uncertainty_score":0.004550636,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02997102207904501,"score_gpt":0.2867668724241957,"score_spread":0.2567958503451507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}