{"id":"W4400190320","doi":"10.1021/acs.jmedchem.4c00665","title":"Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for <i>In Vivo</i> Mouse Studies","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; Penetrant (biochemical); Allosteric regulation; Pharmacology; In vivo; Agonist; Receptor; Orphan receptor; Biochemistry; Genetics; Medicine; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004067778,0.0005667452,0.000367063,0.0004458049,0.0001622078,0.0003986235,0.0007005052,0.0005430107,0.002333539],"category_scores_gemma":[0.000217856,0.0002658199,0.0003597212,0.0002302868,0.0002298672,0.0004048603,0.0002633026,0.00113367,0.001218372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003659727,"about_ca_system_score_gemma":0.0003691773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004881581,"about_ca_topic_score_gemma":0.0009463153,"domain_scores_codex":[0.9998493,0.00002860488,0.00001084632,0.0000276239,0.00004410765,0.00003946874],"domain_scores_gemma":[0.9999158,0.00000854592,0.00002173062,0.00001107394,0.00001444845,0.00002838733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003364576,0.0001488829,0.0001312166,0.0001369879,0.0000231034,0.0001379642,0.00002889426,0.0003853533,0.9841347,0.001462064,0.0009902649,0.01208401],"study_design_scores_gemma":[0.0002821842,0.00367946,0.001180545,0.00004679831,0.00007474834,0.000999787,0.00002450101,0.001499156,0.966494,0.0003181005,0.02537346,0.00002731865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9104012,0.00849317,0.04904226,0.001667732,0.0002786146,0.0009468204,0.005327884,0.001225218,0.02261709],"genre_scores_gemma":[0.9372146,0.006493771,0.03739144,0.0007292198,0.00003288483,0.000510243,0.00407141,0.0001290688,0.01342744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002333539,"threshold_uncertainty_score":0.00780648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582620905256018,"score_gpt":0.290317624114019,"score_spread":0.2744914150614588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}