{"id":"W4400193364","doi":"10.1136/gutjnl-2024-bsg.27","title":"O27 BMJ Open Gastroenterology best clinical science abstract: endoscopic outcomes from PROFILE: a multi-centre, randomised, open-label, biomarker-stratified clinical trial of treatment strategies for patients with newly-diagnosed Crohn’s disease","year":2024,"lang":"en","type":"article","venue":"Oral Presentations","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Biomarker; Internal medicine; Open label; Gastroenterology; Crohn's disease; Clinical trial; Medical physics; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006172947,0.0003017483,0.0005202336,0.00007721733,0.0001958169,0.0005567372,0.0008648581,0.0001246603,0.00009642567],"category_scores_gemma":[0.0007822672,0.0002284022,0.0002019781,0.0001157387,0.0007292227,0.0001271917,0.0003647513,0.0001013241,0.00001652945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003587191,"about_ca_system_score_gemma":0.002320193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003193028,"about_ca_topic_score_gemma":0.0008217699,"domain_scores_codex":[0.9969921,0.0003272725,0.001137855,0.0009106984,0.000237724,0.0003944248],"domain_scores_gemma":[0.9979042,0.0003845924,0.000351641,0.0006766935,0.0002934743,0.0003894432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3517798,0.01266309,0.6247459,0.000102307,0.001160526,0.0002023348,0.000102295,0.00006724781,0.00105346,0.000200871,0.002944721,0.004977436],"study_design_scores_gemma":[0.3411737,0.002140208,0.6545444,0.00005804512,0.0004333695,2.295616e-7,0.0001882831,0.0007922483,0.0001120294,0.0000810819,0.00026057,0.000215846],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851398,0.00002652854,0.000499704,0.0002095542,0.0007966449,0.01113267,0.002016982,0.00001888456,0.0001592542],"genre_scores_gemma":[0.9892756,0.00003009734,0.006446766,0.00009220634,0.0001466996,0.00203251,0.001530568,0.00003695336,0.0004085963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02979848,"threshold_uncertainty_score":0.9313971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1243677036708903,"score_gpt":0.4505069448553326,"score_spread":0.3261392411844423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}