{"id":"W4400193364","doi":"10.1136/gutjnl-2024-bsg.27","title":"O27 BMJ Open Gastroenterology best clinical science abstract: endoscopic outcomes from PROFILE: a multi-centre, randomised, open-label, biomarker-stratified clinical trial of treatment strategies for patients with newly-diagnosed Crohn’s disease","year":2024,"lang":"en","type":"article","venue":"Oral Presentations","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Biomarker; Internal medicine; Open label; Gastroenterology; Crohn's disease; Clinical trial; Medical physics; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004963432,0.0009921186,0.00196787,0.0007929202,0.0008627985,0.002427924,0.0008735986,0.007199303,0.1459536],"category_scores_gemma":[0.01835003,0.0005837999,0.00173521,0.001127276,0.001289274,0.001515549,0.0009796073,0.003444902,0.01093882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001144729,"about_ca_system_score_gemma":0.004506011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001999136,"about_ca_topic_score_gemma":0.003598368,"domain_scores_codex":[0.9950252,0.003419135,0.0003974718,0.0003383993,0.0005251248,0.0002946672],"domain_scores_gemma":[0.9907942,0.004487923,0.001777184,0.0005383349,0.0009789536,0.001423346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4455081,0.006340917,0.004761299,0.02170082,0.002699796,0.0003993171,0.0003127693,0.00039325,0.00303078,0.004393649,0.3768957,0.1335636],"study_design_scores_gemma":[0.8691422,0.01510044,0.009605817,0.003297394,0.0009988416,0.0001302032,0.0001291018,0.0006927593,0.0003771,0.002471054,0.09799507,0.00006005032],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.2153417,0.05724544,0.004637705,0.1667226,0.03902514,0.1465633,0.1374357,0.00131636,0.2317121],"genre_scores_gemma":[0.5295053,0.03043726,0.01417905,0.1252629,0.04521756,0.1196971,0.02992178,0.0005481745,0.1052309],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.1459536,"threshold_uncertainty_score":0.4882634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1243677036708903,"score_gpt":0.4505069448553326,"score_spread":0.3261392411844423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}