{"id":"W4400208202","doi":"10.1038/s41588-024-01798-4","title":"Understanding the genetic complexity of puberty timing across the allele frequency spectrum","year":2024,"lang":"en","type":"article","venue":"Nature Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Centre for Global Health Research; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Université de Montréal","funders":"National Cancer Institute; Medical Research Foundation; Medical Research Council; Research Councils UK; Novo Nordisk Fonden; National Institute of Environmental Health Sciences","keywords":"Biology; Allele; Allele frequency; Genetics; Evolutionary biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006103221,0.0002895728,0.0002859742,0.0009326857,0.0002100767,0.0005923073,0.0002372059,0.0003785313,0.001672575],"category_scores_gemma":[0.002132145,0.0001663995,0.0003146806,0.0007105034,0.0003218011,0.0003240247,0.0005074982,0.0004849935,0.0001279045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001190307,"about_ca_system_score_gemma":0.0001623494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002616792,"about_ca_topic_score_gemma":0.00349997,"domain_scores_codex":[0.9995048,0.0001316106,0.00002865344,0.0002106253,0.00006203769,0.00006223686],"domain_scores_gemma":[0.9991871,0.0003764596,0.0002544718,0.00009443624,0.00003646829,0.00005120844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003196049,0.00004661637,0.918604,0.00006423612,0.0006823838,0.0006757623,0.0005367069,0.001101339,0.04321806,0.001494781,0.0004711362,0.03278547],"study_design_scores_gemma":[0.000009027045,0.00005832466,0.9939412,0.00001391495,0.0001125241,0.0007791342,0.0001188036,0.001388199,0.001047254,0.001277157,0.001245373,0.000009043254],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944128,0.0008664741,0.003097558,0.0002541088,0.00001172468,0.000007042271,0.0005414895,0.00002790215,0.0007808588],"genre_scores_gemma":[0.9976481,0.0004059926,0.001284083,0.00007027856,0.00002129561,0.000006474621,0.0002707229,0.00001484054,0.0002782732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002616792,"threshold_uncertainty_score":0.005595267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06314701979262892,"score_gpt":0.3308540590002574,"score_spread":0.2677070392076285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}