{"id":"W4400210862","doi":"10.1093/genetics/iyae092","title":"The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences","year":2024,"lang":"en","type":"article","venue":"Genetics","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Cytidine deaminase; Biology; Genetics; Sequence (biology); Activation-induced (cytidine) deaminase; Genome; Computational biology; Feature (linguistics); Cytidine; Whole genome sequencing; Gene; Somatic hypermutation; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009423958,0.0001717171,0.0002207101,0.0002829989,0.0001930903,0.0003871075,0.0001254965,0.0002358024,0.0006781287],"category_scores_gemma":[0.000147368,0.000111114,0.0001472738,0.0003812471,0.0001999513,0.0001158036,0.0002231641,0.0003161426,0.0003262572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003278627,"about_ca_system_score_gemma":0.0002730286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003402223,"about_ca_topic_score_gemma":0.006459461,"domain_scores_codex":[0.9998641,0.00001328964,0.000006725921,0.00003890692,0.0000568004,0.00002020438],"domain_scores_gemma":[0.9998786,0.00001438306,0.00003519889,0.00001288648,0.00003468787,0.0000242787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004152612,0.000008716078,0.002117663,0.00002207216,0.000004112761,0.00005758117,0.00002343301,0.0001458822,0.9913278,0.0002880352,0.00005608281,0.005907053],"study_design_scores_gemma":[0.00001006821,0.0001951668,0.04549672,0.00001335093,0.00003065002,0.002003359,0.00009328124,0.002111175,0.9323661,0.0005269212,0.01712584,0.00002727609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768882,0.001826496,0.01380514,0.0001266204,0.00001494214,0.00002993369,0.0008588489,0.0001857614,0.006264124],"genre_scores_gemma":[0.9874138,0.0005666633,0.0091985,0.00004920524,0.000004797379,0.00001181367,0.0005525395,0.00002506303,0.002177691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003402223,"threshold_uncertainty_score":0.006764889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02312922318054867,"score_gpt":0.249412676636913,"score_spread":0.2262834534563644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}