{"id":"W4400210862","doi":"10.1093/genetics/iyae092","title":"The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences","year":2024,"lang":"en","type":"article","venue":"Genetics","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"Cytidine deaminase; Biology; Genetics; Sequence (biology); Activation-induced (cytidine) deaminase; Genome; Computational biology; Feature (linguistics); Cytidine; Whole genome sequencing; Gene; Somatic hypermutation; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007029063,0.00008417048,0.00004772927,0.000009568313,0.0002330499,0.0002422342,0.000133656,0.00004465266,0.0002469897],"category_scores_gemma":[0.000006492326,0.00005570263,0.00002202632,0.00009365124,0.0002192091,0.00006465073,0.0001364561,0.0001321883,0.0001492049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004693301,"about_ca_system_score_gemma":0.0000147269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008714434,"about_ca_topic_score_gemma":0.0008360161,"domain_scores_codex":[0.9995096,0.00002270733,0.00007337508,0.0001818769,0.0000606763,0.0001517917],"domain_scores_gemma":[0.9997396,0.00004028829,0.00001586123,0.0001463092,0.000004556268,0.0000534268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002961252,0.000007578118,0.0001487912,0.000009436925,0.00001035358,0.00001181593,0.0003589672,0.00006948873,0.9681258,0.0000767327,0.003042589,0.02813545],"study_design_scores_gemma":[0.00003965154,0.00006905721,0.03418193,0.00002114233,0.00002161689,0.0001024043,0.00008987447,0.0005219996,0.02156306,0.0006590876,0.9425887,0.0001414622],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926767,0.002127984,0.0002353409,0.002702547,0.000230026,0.0001328867,0.00003510467,0.00004045246,0.001819012],"genre_scores_gemma":[0.9912186,0.00191808,0.001306194,0.0001167337,0.00005663797,0.000009501719,0.000007021908,0.000009640435,0.005357625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9465628,"threshold_uncertainty_score":0.2704364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02312922318054867,"score_gpt":0.249412676636913,"score_spread":0.2262834534563644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}