{"id":"W4400216817","doi":"10.1002/mds.29897","title":"Research Priorities on the Role of α‐ <scp>Synuclein</scp> in Parkinson's Disease Pathogenesis","year":2024,"lang":"en","type":"review","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network","funders":"National Institute on Aging; Parkinsonfonden; National Institutes of Health; Idorsia Pharmaceuticals; Hellenic Foundation for Research and Innovation; General Secretariat for Research and Technology; University of Oxford; National Health and Medical Research Council; Horizon 2020 Framework Programme; National Institute of Neurological Disorders and Stroke; University of Cambridge; FORUM Pharmaceuticals; Biogen; Pfizer; Parkinson Canada; Australian Government; Canadian Institutes of Health Research; Edmond J. Safra Philanthropic Foundation; Sunovion; Sun Pharma; Fondation Brain Canada; Michael J. Fox Foundation for Parkinson's Research; Johns Hopkins University; Teva Pharmaceutical Industries; Eli Lilly and Company","keywords":"Parkinson's disease; Disease; Movement disorders; Neuroscience; Pathogenesis; Political science; Medicine; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002576455,0.0007652011,0.001850385,0.003188793,0.0004321468,0.001778218,0.001141575,0.00220583,0.005148352],"category_scores_gemma":[0.001784936,0.0002990578,0.0009706231,0.003071349,0.0006067092,0.002742561,0.0008442968,0.002853849,0.002215687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001268212,"about_ca_system_score_gemma":0.00417194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002167804,"about_ca_topic_score_gemma":0.003794966,"domain_scores_codex":[0.9996185,0.00008305498,0.00006833833,0.00004854109,0.0001278077,0.00005370642],"domain_scores_gemma":[0.998458,0.0007709902,0.0001724401,0.00003352826,0.0004571567,0.0001078671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001480846,0.00007725514,0.0001835164,0.04419029,0.0001283241,0.0004101139,0.0001732865,0.0003887472,0.001770725,0.01123919,0.08077487,0.8605156],"study_design_scores_gemma":[0.00002704068,0.00009031002,0.0006495575,0.01953142,0.0002428959,0.0007935255,0.0001477477,0.00008250171,0.000252705,0.003364733,0.9747965,0.00002105465],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007763115,0.9970035,0.00005556626,0.001340969,0.0004592022,0.000005669537,0.00001847531,0.000007390528,0.001031537],"genre_scores_gemma":[0.0004814584,0.9978492,0.0001740665,0.0007340289,0.0002831928,0.000007318847,0.00003243111,0.000001230074,0.0004370114],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005148352,"threshold_uncertainty_score":0.01722294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04555498134728735,"score_gpt":0.3375442612087802,"score_spread":0.2919892798614928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}