{"id":"W4400219326","doi":"10.1101/2024.06.26.600903","title":"Loss of neurofibromin accelerates uveal and dermal melanoma formation driven by GNAQ","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"GNAQ; Haploinsufficiency; Melanoma; Neurofibromin 1; Cancer research; Neuroblastoma RAS viral oncogene homolog; CDKN2A; Biology; Melanocyte; Pathology; Neurofibromatosis; Medicine; Gene; Mutation; Phenotype; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327783,0.0002913081,0.0001663307,0.0003230199,0.0001158483,0.0001865056,0.000137628,0.0002528929,0.001726504],"category_scores_gemma":[0.00009677861,0.000127644,0.0001657635,0.00008882273,0.0002291352,0.0001142998,0.0002016832,0.0005216611,0.0004131302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000229624,"about_ca_system_score_gemma":0.0001257159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007252096,"about_ca_topic_score_gemma":0.001110036,"domain_scores_codex":[0.9998646,0.00002731095,0.00001084469,0.00002438459,0.00004132717,0.00003144653],"domain_scores_gemma":[0.999842,0.00002734187,0.00005412276,0.00001589004,0.00001046191,0.00005011317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005385249,0.00001696212,0.0001452219,0.000006781664,0.000001186632,0.00004953055,0.000006000313,0.00001557399,0.9993765,0.00003192261,0.0000145627,0.0002819162],"study_design_scores_gemma":[0.00001382584,0.0002632311,0.006456286,0.000002964016,0.000005158393,0.0003810081,0.00002896005,0.0004979438,0.9910957,0.00002950517,0.001223134,0.000002252847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997372,0.0003521615,0.0009970865,0.00006024035,0.00001191707,0.00001694235,0.0001918355,0.00006335584,0.000934422],"genre_scores_gemma":[0.9936481,0.0002409712,0.0009494616,0.00002814688,0.000004698799,0.00001748655,0.0002293857,0.00003047874,0.004851219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001726504,"threshold_uncertainty_score":0.00577575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214570102786775,"score_gpt":0.2396303592707082,"score_spread":0.2274846582428405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}