{"id":"W4400229714","doi":"10.3390/vaccines12070733","title":"Determination of Deamidation in Adjuvanted Vaccine Antigens through Isoaspartic Acid Quantification","year":2024,"lang":"en","type":"article","venue":"Vaccines","topic":"Protein purification and stability","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Sanofi","keywords":"Deamidation; Immunogenicity; Antigen; Chemistry; Biochemistry; Biology; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002120119,0.00008604254,0.0001013058,0.00007201364,0.00002201681,0.00001619376,0.00008967101,0.00008419259,0.00003139896],"category_scores_gemma":[0.0001573165,0.00007970801,0.00004195969,0.0002581835,0.00001027867,0.00001605709,0.00002167977,0.0000440068,0.00001237792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001199402,"about_ca_system_score_gemma":0.00003895973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002484426,"about_ca_topic_score_gemma":0.0001327519,"domain_scores_codex":[0.9992025,0.00005724542,0.0002975267,0.0002681825,0.00007180438,0.0001027315],"domain_scores_gemma":[0.9995416,0.00001306604,0.00006069378,0.000270365,0.00009728088,0.00001702792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000647543,0.00006691535,0.007030291,0.0001005505,0.000007646763,6.496757e-7,0.0001270756,0.00001325716,0.9695707,0.0006686504,0.0000906861,0.02225882],"study_design_scores_gemma":[0.0002770081,0.00007953494,0.08331019,0.000039117,0.00001079469,0.000003721311,0.0000509679,0.004551379,0.9056332,0.0006849989,0.005252234,0.0001068404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9516502,0.003781954,0.04343432,0.000523172,0.0001518928,0.0002635439,0.00001320246,0.00002813674,0.0001536019],"genre_scores_gemma":[0.9979935,0.0003792856,0.001209746,0.00002398445,0.00005148717,0.00003372211,0.0001881683,0.0000105012,0.0001096119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0762799,"threshold_uncertainty_score":0.3250398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856555256733208,"score_gpt":0.2986339577054897,"score_spread":0.2800684051381577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}