{"id":"W4400238014","doi":"10.1172/jci.insight.175047","title":"Thrombospondin-1 promotes fibro-adipogenic stromal expansion and contractile dysfunction of the diaphragm in obesity","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"Body Contouring and Surgery","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; NIH Office of the Director; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Medical School, University of Michigan","keywords":"Adipogenesis; Stromal cell; Internal medicine; Diaphragm (acoustics); Thrombospondin 1; Thrombospondin; Endocrinology; Medicine; Obesity; Chemistry; Cardiology; Adipose tissue; Physics; Angiogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000170386,0.0002272385,0.0002255395,0.0002239278,0.0001145379,0.0001904916,0.00009661246,0.0002411955,0.001210985],"category_scores_gemma":[0.0001056031,0.0001750265,0.0002290835,0.00009793658,0.0002107554,0.0001490018,0.0002093682,0.0006711662,0.0001890765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000137636,"about_ca_system_score_gemma":0.0001105529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002367896,"about_ca_topic_score_gemma":0.0005033648,"domain_scores_codex":[0.9998978,0.0000182449,0.000009626102,0.00002564577,0.00002864771,0.00002003006],"domain_scores_gemma":[0.9998647,0.00001115821,0.0000471729,0.000009179583,0.00001260211,0.00005509614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002315301,0.0000349123,0.001415846,0.00004732223,0.000008481859,0.00009053912,0.00001458251,0.00002741625,0.9973762,0.0000427345,0.00003952981,0.0006710798],"study_design_scores_gemma":[0.0001075187,0.001803625,0.2641458,0.0000511634,0.00009822928,0.002236086,0.000285455,0.00176533,0.725782,0.0002565426,0.003454141,0.00001417902],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996946,0.001323255,0.0008849833,0.00008712424,0.00001725928,0.00001180216,0.0002945411,0.00003008812,0.0004049359],"genre_scores_gemma":[0.9964166,0.0009536236,0.0006301078,0.00008500535,0.00001142896,0.00002742213,0.0004594573,0.00001060602,0.001405826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001210985,"threshold_uncertainty_score":0.004051149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102297849851283,"score_gpt":0.2353382102445965,"score_spread":0.2243152317460836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}