{"id":"W4400242718","doi":"10.1128/mbio.00907-24","title":"Temperature-dependent Spike-ACE2 interaction of Omicron subvariants is associated with viral transmission","year":2024,"lang":"en","type":"article","venue":"mBio","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mila - Quebec Artificial Intelligence Institute; Institute of Infection and Immunity; University of Ottawa; Institut National de Santé Publique du Québec; Montreal Heart Institute; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Uniformed Services University of the Health Sciences; Mitacs; Fondation du CHUM; U.S. Department of Defense","keywords":"Neutralization; Glycoprotein; Chemistry; Spike (software development); Biophysics; Virology; Biology; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212136,0.0001254614,0.0002178122,0.0001507714,0.00003761812,0.00004878904,0.00007231186,0.000142014,0.00009642741],"category_scores_gemma":[0.00003198645,0.00008908088,0.00008200203,0.0002518695,0.00003886334,0.0001122227,0.00001793203,0.0003639768,0.00006387064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001770642,"about_ca_system_score_gemma":0.0002006041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002055432,"about_ca_topic_score_gemma":0.0000277837,"domain_scores_codex":[0.9989366,0.00004118486,0.0001867863,0.0002635466,0.0003656789,0.000206182],"domain_scores_gemma":[0.9996359,0.00004554096,0.00003226338,0.0001678663,0.00008466958,0.00003379384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007426429,0.0001756287,0.003333233,0.0001835414,0.0001229943,0.0001939986,0.0007305394,2.284578e-7,0.9875221,0.00001984239,0.001757189,0.005218037],"study_design_scores_gemma":[0.00131053,0.0006390758,0.003846295,0.0007208335,0.00008571455,0.00005563246,0.0001168228,0.0005573309,0.961202,0.00003005743,0.0313219,0.0001138601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959859,0.000608039,0.0001372958,0.0007023632,0.0001972594,0.0002530431,0.00001673501,0.00008527091,0.002014104],"genre_scores_gemma":[0.9963989,0.000008501271,0.00003306445,0.002779205,0.00007803509,0.000009125731,0.00001237831,0.00002809385,0.0006526795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02956471,"threshold_uncertainty_score":0.3632613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02227661461455355,"score_gpt":0.3269196154673276,"score_spread":0.3046430008527741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}