{"id":"W4400242949","doi":"10.1021/acs.analchem.3c05018","title":"MOTAI: A Novel Method for the Study of O-GalNAcylation and Complex O-Glycosylation in Cancer","year":2024,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Institute of Dental and Craniofacial Research; Shuangchuang Program of Jiangsu Province; Government of Jiangsu Province; Priority Academic Program Development of Jiangsu Higher Education Institutions; Jiangsu Science and Technology Department; Soochow University; Suzhou Municipal Health Commission","keywords":"Glycosylation; Glycoprotein; Chemistry; Cancer; Fucose; Biochemistry; N-linked glycosylation; Glycome; Biomarker; Colorectal cancer; Cancer research; Molecular biology; Glycan; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005402775,0.001231339,0.0005521444,0.001437445,0.0004951424,0.000401175,0.0006545656,0.000898395,0.002190198],"category_scores_gemma":[0.0003601756,0.0004731642,0.0005574503,0.0008867384,0.0003615268,0.0007798185,0.0007350742,0.001660364,0.0010604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271003,"about_ca_system_score_gemma":0.0003260579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005582322,"about_ca_topic_score_gemma":0.001148836,"domain_scores_codex":[0.999666,0.00007311605,0.00001829926,0.00007632797,0.0001147812,0.00005151466],"domain_scores_gemma":[0.9997786,0.00005302804,0.00005200497,0.00002966615,0.00004279563,0.00004402166],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007603722,0.00001967974,0.0002844346,0.000213213,0.00002683745,0.00009925931,0.00004724753,0.00006663555,0.9828244,0.0004094222,0.0005434503,0.0153894],"study_design_scores_gemma":[0.00003661633,0.0002667957,0.003731855,0.00003563482,0.00006248453,0.001330663,0.00005898014,0.004375068,0.95098,0.0003843367,0.03868045,0.00005709153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2498492,0.04306887,0.6848868,0.001508098,0.001049174,0.0009573609,0.002690409,0.005043578,0.01094649],"genre_scores_gemma":[0.3131236,0.02260086,0.6289277,0.0008955946,0.0002159597,0.001885989,0.004952086,0.0006423451,0.02675579],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002190198,"threshold_uncertainty_score":0.007326961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05974738083333123,"score_gpt":0.4099623764053145,"score_spread":0.3502149955719832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}