{"id":"W4400248386","doi":"10.1038/s41467-024-49738-4","title":"Cyprocide selectively kills nematodes via cytochrome P450 bioactivation","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Nematode management and characterization studies","field":"Agricultural and Biological Sciences","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Occupational Cancer Research Centre; University of Toronto","funders":"Agriculture and Agri-Food Canada; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; U.S. Department of Agriculture; Canada Research Chairs; University of Toronto","keywords":"Nematode; Cytochrome P450; Biology; Chemistry; Biotechnology; Biochemistry; Enzyme; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001245274,0.0002453823,0.0001325387,0.000168551,0.0001051878,0.0001642182,0.0001414381,0.0002167083,0.0007728456],"category_scores_gemma":[0.000135304,0.00006961126,0.0001395003,0.0001242245,0.0001540129,0.0002150191,0.0001357639,0.0003051441,0.0002467207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001712561,"about_ca_system_score_gemma":0.0001381116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003233668,"about_ca_topic_score_gemma":0.0007809402,"domain_scores_codex":[0.9998939,0.00001715794,0.000006103638,0.00002360108,0.00003889669,0.00002040887],"domain_scores_gemma":[0.9999312,0.000008086417,0.00002636281,0.000008511864,0.000016366,0.000009523713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000231354,0.00001348825,0.0002296109,0.00004112976,0.000004432839,0.00006736765,0.00001034518,0.00008191885,0.9971004,0.00009176103,0.00006771393,0.002268685],"study_design_scores_gemma":[0.000007004838,0.0004781105,0.001790299,0.000005129372,0.000008751331,0.0003017191,0.00001705524,0.0002894491,0.9939553,0.0000372934,0.003106083,0.000003770299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830841,0.002627934,0.00811155,0.0002672513,0.00003101582,0.00008434576,0.0004515842,0.0001058928,0.005236194],"genre_scores_gemma":[0.9922121,0.002093472,0.002835254,0.00007299831,0.00001148581,0.00001901313,0.0003406382,0.000009528463,0.002405644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007728456,"threshold_uncertainty_score":0.002585411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972921314497287,"score_gpt":0.2745842807883777,"score_spread":0.2548550676434048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}