{"id":"W4400249054","doi":"10.1038/s41467-024-48985-9","title":"HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University; Western University","funders":"NHLBI Division of Intramural Research; National Institute of Allergy and Infectious Diseases; New Partnership for Africa's Development; National Institutes of Health; U.S. Department of Health and Human Services; Canada Research Chairs; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Government of the United Kingdom; Michael Smith Health Research BC; Massachusetts General Hospital; Wellcome Trust; Alliance for Accelerating Excellence in Science in Africa; African Academy of Sciences; Canadian Institutes of Health Research; Wellcome; Government of Canada","keywords":"Provirus; Genome; Recombinant DNA; Virology; Biology; Human immunodeficiency virus (HIV); Antiretroviral therapy; Genetics; Gene; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002740635,0.00009657074,0.0002184665,0.0002660778,0.0002660514,0.0004556265,0.0001299325,0.0002469101,0.0009278392],"category_scores_gemma":[0.000789571,0.0001332767,0.0001011325,0.000240241,0.0002216458,0.000248542,0.0002028482,0.0002705831,0.0001639717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002197712,"about_ca_system_score_gemma":0.0001159653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007709927,"about_ca_topic_score_gemma":0.0008099998,"domain_scores_codex":[0.9998112,0.00004815462,0.000007505522,0.00003372691,0.00004348785,0.0000558483],"domain_scores_gemma":[0.9997481,0.00008317419,0.00005549321,0.00002292459,0.00004509991,0.0000452432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001432943,0.0001318918,0.1302684,0.00006377566,0.00003487087,0.0007004596,0.0008825053,0.0008545447,0.8257232,0.000199399,0.0002180209,0.03949011],"study_design_scores_gemma":[0.00003531055,0.00198841,0.8309581,0.00002919115,0.00006475471,0.004015959,0.001220884,0.00361421,0.1543301,0.000477614,0.003239948,0.00002546163],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987293,0.0003946831,0.0002368867,0.00001324396,0.000001014273,0.000004653049,0.00006030564,0.000004307793,0.0005554838],"genre_scores_gemma":[0.9990865,0.0001072853,0.0002007112,0.00002583254,0.000003002395,0.000007922602,0.0001321091,0.000004686337,0.0004320344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009278392,"threshold_uncertainty_score":0.003103912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532566894410652,"score_gpt":0.2941961189897793,"score_spread":0.2788704500456727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}