{"id":"W4400258544","doi":"10.1039/d4pm00079j","title":"Effect of leucine as an aerosolization enhancer on the bioactivity of spray dried viral-vectored vaccines for inhalation","year":2024,"lang":"en","type":"article","venue":"RSC Pharmaceutics","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; University of British Columbia; McMaster University Medical Centre; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aerosolization; Inhalation; Spray drying; Leucine; Chemistry; Pharmacology; Virology; Medicine; Chromatography; Biochemistry; Anesthesia; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002257437,0.0002729003,0.0002031804,0.00008337216,0.00009379168,0.000181902,0.0001704945,0.0002175359,0.0008822305],"category_scores_gemma":[0.0002536127,0.00008881849,0.0001989514,0.00006410192,0.000198076,0.0002125588,0.0001288561,0.0003855542,0.000147617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462588,"about_ca_system_score_gemma":0.0001970559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007995752,"about_ca_topic_score_gemma":0.0009050281,"domain_scores_codex":[0.9998888,0.00002575603,0.000009492715,0.00002409421,0.00002663567,0.00002521524],"domain_scores_gemma":[0.9998426,0.00007253981,0.00003144281,0.000008851099,0.00002607325,0.00001834251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001166184,0.00002036616,0.0000463207,0.00002655253,0.000002480127,0.00001537074,0.00001111129,0.00005117528,0.9989161,0.0000110643,0.00001060711,0.0007723078],"study_design_scores_gemma":[0.00000465967,0.0003382503,0.0004338036,0.000002025771,0.000005124264,0.00002056155,0.000005959741,0.0002939529,0.9986865,0.000003277143,0.0002033362,0.000002580653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966962,0.001233666,0.001333634,0.0000402846,0.00002370808,0.00002417804,0.000072959,0.00002742146,0.0005480085],"genre_scores_gemma":[0.9952685,0.0007418045,0.003005366,0.0000407733,0.00001117515,0.0000191853,0.00008876954,0.00002070498,0.0008036587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008822305,"threshold_uncertainty_score":0.002951384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03369203844170554,"score_gpt":0.3898450259955381,"score_spread":0.3561529875538326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}