{"id":"W4400261672","doi":"10.1016/j.ymthe.2024.06.038","title":"Discovery of a novel inhibitor of macropinocytosis with antiviral activity","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; Science for Life Laboratory; Karolinska Institutet; Uppsala Universitet; Vetenskapsrådet; Human Frontier Science Program; HORIZON EUROPE Marie Sklodowska-Curie Actions; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden; European Federation of Pharmaceutical Industries and Associations; McGill University","keywords":"Pinocytosis; Endocytosis; Viral entry; Biology; Virus; Infectivity; Virology; Limiting; Viral envelope; Cell biology; Viral replication; Cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001545096,0.0003734982,0.0003287914,0.0002654418,0.000162524,0.0002902026,0.0003215772,0.0003615347,0.001122473],"category_scores_gemma":[0.00009170923,0.0001340231,0.000309747,0.0001380919,0.000141615,0.0002222357,0.0002357017,0.0007182269,0.000358971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002562057,"about_ca_system_score_gemma":0.0002656952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002995161,"about_ca_topic_score_gemma":0.0007311243,"domain_scores_codex":[0.9999423,0.000006682451,0.000004143305,0.00001257691,0.00001901479,0.00001519463],"domain_scores_gemma":[0.999963,0.000006318796,0.000007589768,0.000002935931,0.000009200557,0.00001086275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001498482,0.0001642326,0.0002564888,0.0003015357,0.00003423251,0.0002256742,0.00003423601,0.0004643518,0.9734422,0.0007475382,0.0005999854,0.02357971],"study_design_scores_gemma":[0.0002886479,0.002672812,0.002703381,0.00006082272,0.00009469615,0.0010448,0.00002907458,0.002512373,0.9600002,0.0002484882,0.03031765,0.00002725447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8899296,0.04636528,0.03208961,0.001405533,0.0004129478,0.0009344792,0.001664263,0.0005837703,0.0266145],"genre_scores_gemma":[0.9603894,0.01577197,0.01381011,0.0007438961,0.00005521882,0.000266153,0.001234438,0.00003650943,0.007692331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001122473,"threshold_uncertainty_score":0.003755033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009936943471723799,"score_gpt":0.2347641686673206,"score_spread":0.2248272251955968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}