{"id":"W4400261672","doi":"10.1016/j.ymthe.2024.06.038","title":"Discovery of a novel inhibitor of macropinocytosis with antiviral activity","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 Marie Skłodowska-Curie Actions; Science for Life Laboratory; Karolinska Institutet; Uppsala Universitet; Vetenskapsrådet; Human Frontier Science Program; HORIZON EUROPE Marie Sklodowska-Curie Actions; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden; European Federation of Pharmaceutical Industries and Associations; McGill University","keywords":"Pinocytosis; Endocytosis; Viral entry; Biology; Virus; Infectivity; Virology; Limiting; Viral envelope; Cell biology; Viral replication; Cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006359506,0.0001224184,0.0001478943,0.00004654824,0.00001319759,0.00001452247,0.00008384616,0.00008306856,0.000003948118],"category_scores_gemma":[0.000001851612,0.0000973138,0.0001394516,0.0001227081,0.00009198524,0.000007493335,0.00001475062,0.00005621603,5.390193e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004813322,"about_ca_system_score_gemma":0.00005903637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003252135,"about_ca_topic_score_gemma":0.000009231147,"domain_scores_codex":[0.999372,0.00001950629,0.0001245796,0.0002311987,0.0001394706,0.0001132284],"domain_scores_gemma":[0.9996744,0.000003574426,0.00004426226,0.0002244083,0.00003636454,0.00001694629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004319632,0.0001387345,0.0008489051,0.00006342385,0.0001476508,0.00001023104,0.00005324309,0.0000157293,0.9951675,0.000200925,0.000003960708,0.002917736],"study_design_scores_gemma":[0.0006177142,0.0005038445,0.001323646,0.00005756003,0.0000186718,0.000004629598,0.00001026739,0.0000905737,0.9950185,0.00001219,0.002222202,0.0001201986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8386258,0.001646089,0.1593062,0.0000358878,0.00005582995,0.0001209277,0.00003666244,0.000007836195,0.0001647324],"genre_scores_gemma":[0.9988431,0.0003162946,0.0004010845,0.00002495316,0.00004183026,0.000007400679,0.0002289344,0.00002583745,0.0001105136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1602173,"threshold_uncertainty_score":0.3968342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009936943471723799,"score_gpt":0.2347641686673206,"score_spread":0.2248272251955968,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}