{"id":"W4400261881","doi":"10.1080/19491034.2024.2374854","title":"Sensing the squeeze: nuclear mechanotransduction in health and disease","year":2024,"lang":"en","type":"article","venue":"Nucleus","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Mechanotransduction; Mechanosensation; Mechanosensitive channels; Neuroscience; Biology; Nucleus; Function (biology); Cell biology; Genetics; Ion channel","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009013072,0.00006293393,0.00004605427,0.00002424498,0.00007216159,0.00004476953,0.00003121778,0.00004193798,0.00001423784],"category_scores_gemma":[0.00001947484,0.00004721224,0.00002669894,0.00006351612,0.00003207656,0.000003707384,0.00002101846,0.00008311679,0.000008483423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001230429,"about_ca_system_score_gemma":0.00003873559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003721438,"about_ca_topic_score_gemma":0.00001871081,"domain_scores_codex":[0.9995397,0.00003505022,0.00008089151,0.0001852183,0.00005114173,0.0001079906],"domain_scores_gemma":[0.9997799,0.000003334355,0.00001168535,0.0001211016,0.000007305245,0.00007665744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006130299,0.00004109435,0.0002916391,0.0004070711,0.00008245856,0.00005196382,0.002215029,0.0001739802,0.3822537,0.01937275,0.02992751,0.5645698],"study_design_scores_gemma":[0.000257063,0.000207603,0.002144007,0.0000732046,0.00001409826,0.00006270949,0.0003718211,0.005302292,0.0008240295,0.002840379,0.9877327,0.0001701033],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877241,0.00272621,0.000704521,0.00742193,0.0006895028,0.0001642958,0.000008462446,0.00004723766,0.000513765],"genre_scores_gemma":[0.9977946,0.0003160663,0.0002358839,0.001228808,0.0002557113,6.518137e-7,0.00001298795,0.0000200274,0.000135222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9578052,"threshold_uncertainty_score":0.1925259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005711468953766571,"score_gpt":0.2257652826035212,"score_spread":0.2200538136497546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}