{"id":"W4400261881","doi":"10.1080/19491034.2024.2374854","title":"Sensing the squeeze: nuclear mechanotransduction in health and disease","year":2024,"lang":"en","type":"article","venue":"Nucleus","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Mechanotransduction; Mechanosensation; Mechanosensitive channels; Neuroscience; Biology; Nucleus; Function (biology); Cell biology; Genetics; Ion channel","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003877897,0.0005495533,0.0009117593,0.0007990387,0.0005452816,0.001713122,0.000648297,0.001609464,0.002127099],"category_scores_gemma":[0.0003415525,0.0001914746,0.0003578264,0.0008512407,0.001448757,0.002131811,0.000891994,0.001527379,0.0008913178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008062933,"about_ca_system_score_gemma":0.0007981061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006202709,"about_ca_topic_score_gemma":0.0009253725,"domain_scores_codex":[0.9998357,0.00003554862,0.00001384759,0.00003355692,0.0000532197,0.00002801947],"domain_scores_gemma":[0.9998817,0.00004380315,0.00002068073,0.000005068093,0.00003021865,0.00001833447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000419447,0.00007823983,0.001202184,0.01430504,0.000201857,0.002139146,0.00109475,0.001444886,0.05487418,0.09008194,0.05385898,0.7802994],"study_design_scores_gemma":[0.00001363457,0.0002416644,0.002890052,0.002198675,0.0000920757,0.005482382,0.0007569124,0.0003918189,0.008182154,0.03405942,0.9456167,0.00007452821],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.001178306,0.9917189,0.001473454,0.00224863,0.001266038,0.00000602964,0.00001778725,0.0000187467,0.002072124],"genre_scores_gemma":[0.01018882,0.9837404,0.0007550226,0.001169914,0.001445701,0.000008323109,0.00003292978,0.000006227589,0.002652676],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002127099,"threshold_uncertainty_score":0.007115901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005711468953766571,"score_gpt":0.2257652826035212,"score_spread":0.2200538136497546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}