{"id":"W4400264930","doi":"10.1038/s41467-024-48921-x","title":"Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Innovative Medicines Initiative; Kungliga Tekniska Högskolan; European Commission; Research Councils UK; Medical Research Council; European Federation of Pharmaceutical Industries and Associations; McGill University; Diamond Light Source; Wellcome Trust","keywords":"Proline; Transporter; Amino acid; Chemistry; Biochemistry; Protein structure; Receptor; Cytoplasm; Coronavirus disease 2019 (COVID-19); Peptide sequence; Cell biology; Biology; Gene; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113312,0.0002764695,0.0004373137,0.0002589836,0.0003776628,0.000453747,0.0003971769,0.0005467591,0.001242124],"category_scores_gemma":[0.0002187039,0.000195635,0.0002911474,0.0002569986,0.0002354802,0.0002393699,0.0002057763,0.0005156361,0.000384022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008580781,"about_ca_system_score_gemma":0.000170044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003587935,"about_ca_topic_score_gemma":0.002671825,"domain_scores_codex":[0.9998994,0.00001177198,0.000007400362,0.00002568245,0.00003480961,0.00002091434],"domain_scores_gemma":[0.9998916,0.00001489296,0.00003417522,0.000006368562,0.00001790714,0.00003502736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005318485,0.00004330801,0.005709153,0.0001012912,0.00005288562,0.001533826,0.0001906896,0.0008008619,0.9891075,0.000413689,0.0004840026,0.001030869],"study_design_scores_gemma":[0.0002508333,0.0005980296,0.2248502,0.00005862157,0.0001631467,0.01135187,0.001342731,0.1103608,0.6379737,0.0006461125,0.01222929,0.0001745916],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983734,0.0004700609,0.0003294706,0.0002153011,0.000008564948,0.000002498256,0.0002267197,0.0000218224,0.0003521322],"genre_scores_gemma":[0.9966091,0.0004139527,0.0006041952,0.00008254105,0.0000112651,0.000003477667,0.001307686,0.00001497138,0.0009527741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003587935,"threshold_uncertainty_score":0.00713408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432230576190113,"score_gpt":0.278137415236173,"score_spread":0.2638151094742719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}