{"id":"W4400266836","doi":"10.1007/s00262-024-03740-3","title":"Impact of fludarabine and treosulfan on ovarian tumor cells and mesothelin chimeric antigen receptor T cells","year":2024,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Karolinska Institutet; Cancerfonden; Memorial Sloan-Kettering Cancer Center","keywords":"Treosulfan; Mesothelin; Fludarabine; Cancer research; Ovarian cancer; Medicine; Immunology; Antigen; Cancer; Internal medicine; Chemotherapy; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007912212,0.0002594497,0.0002103074,0.00008062831,0.0000742081,0.0001414809,0.0001132743,0.0001587108,0.0009294651],"category_scores_gemma":[0.00009224583,0.00005103733,0.0001726929,0.00006726001,0.00007645009,0.0001085929,0.00009421666,0.0002111621,0.0001639544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001227535,"about_ca_system_score_gemma":0.0001654234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001001071,"about_ca_topic_score_gemma":0.001385215,"domain_scores_codex":[0.999893,0.00002857551,0.000009653579,0.00001873336,0.00002312013,0.00002698098],"domain_scores_gemma":[0.9999396,0.00001405687,0.00001273279,0.000008646291,0.000009299625,0.00001565689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004347317,0.00005198729,0.0003446073,0.00003324554,0.000007834713,0.00006105333,0.00001800959,0.0001994268,0.9967611,0.00005493414,0.00004092353,0.00199214],"study_design_scores_gemma":[0.00002605318,0.001477115,0.003642194,0.000003738231,0.00001849347,0.0001800118,0.00002176821,0.0004635503,0.9923682,0.00001550389,0.001780796,0.000002669808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977488,0.0007407733,0.0004670885,0.00002869835,0.00001458289,0.00002345895,0.0001538652,0.00001461018,0.0008080338],"genre_scores_gemma":[0.9975982,0.0003244797,0.0005803215,0.00003462378,0.000006796429,0.00002329361,0.0002985506,0.000005259692,0.001128492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001071,"threshold_uncertainty_score":0.003109396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734164219113296,"score_gpt":0.3303352799568618,"score_spread":0.3129936377657289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}