{"id":"W4400269853","doi":"10.1101/2024.07.02.601655","title":"Design, infectability, and transcriptomic analysis of transregionally differentiated and scalable lung organoids derived from adult bronchial cells","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill Genome Centre; Health Canada; McGill University","funders":"Institut de Recherche Clinique De Montréal; National Institutes of Health; McGill University Health Centre; Consejo Nacional de Ciencia y Tecnología; McGill University","keywords":"Organoid; Lung; Transcriptome; Biology; Cell culture; Cell biology; Cell; Medicine; Gene; Internal medicine; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004002759,0.0003255218,0.0003311043,0.0002870927,0.000209144,0.0004625277,0.0002709386,0.0003128427,0.0003868085],"category_scores_gemma":[0.0002482696,0.0002038429,0.0004525738,0.000231091,0.0002557334,0.0002123979,0.00032656,0.0006270214,0.0004432001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003248713,"about_ca_system_score_gemma":0.0002517493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005684022,"about_ca_topic_score_gemma":0.001150095,"domain_scores_codex":[0.9997646,0.00002330123,0.00003135248,0.00007278867,0.00007442014,0.00003355284],"domain_scores_gemma":[0.9997422,0.00004775125,0.00006149184,0.00003747603,0.00006299314,0.00004804094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001187851,0.000004832011,0.00006869536,0.000020838,0.000001551975,0.0000218887,0.00001344785,0.00008211548,0.9993821,0.00002634883,0.00001114017,0.0003550567],"study_design_scores_gemma":[0.000004592654,0.0001568177,0.002397588,0.000008831768,0.00001772607,0.0001052308,0.00005722028,0.001015525,0.9932834,0.0000325729,0.002910793,0.000009717142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9184095,0.002501115,0.0714392,0.0001478789,0.0001095736,0.0005226343,0.003818627,0.0003714776,0.002679982],"genre_scores_gemma":[0.896762,0.002678599,0.08557737,0.0001519308,0.0000157367,0.0009685512,0.00751507,0.0001767599,0.006154045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005684022,"threshold_uncertainty_score":0.002357125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01965775975014779,"score_gpt":0.2673062858425398,"score_spread":0.247648526092392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}