{"id":"W4400270189","doi":"10.1186/s12967-024-05428-9","title":"Accumulation of liposomes in metastatic tumor sites is not necessary for anti-cancer drug efficacy","year":2024,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Innovation Council; Spinal Cord Injury BC; University of British Columbia","funders":"Canadian Institutes of Health Research; Ministry of Education, India; Canadian Cancer Society","keywords":"Liposome; Distribution (mathematics); In vivo; Medicine; Cancer; Cancer research; Ex vivo; Metastatic breast cancer; Breast cancer; Drug delivery; Pathology; Pharmacology; Chemistry; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002441066,0.0002873994,0.0005287633,0.0002085879,0.0001921309,0.0005936366,0.0001604939,0.0003684149,0.002722606],"category_scores_gemma":[0.0004996576,0.0002192796,0.0002674948,0.0001222172,0.0003023755,0.0005790187,0.0002840531,0.0006404119,0.0007830014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006096593,"about_ca_system_score_gemma":0.0004783098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008901755,"about_ca_topic_score_gemma":0.000909182,"domain_scores_codex":[0.9997235,0.0000408119,0.00002867756,0.00006296558,0.00008077374,0.00006317238],"domain_scores_gemma":[0.999531,0.0001093313,0.0001147794,0.00006881563,0.0001015799,0.00007445201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001175786,0.00003124603,0.0004922176,0.00007932043,0.000006442924,0.00008279734,0.00001104668,0.0001205003,0.9966877,0.000223627,0.000125009,0.002022473],"study_design_scores_gemma":[0.0000210941,0.0004295257,0.006014128,0.00001983493,0.00002644159,0.0006902702,0.0000286845,0.001674495,0.9865028,0.000164678,0.004420576,0.000007519814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702627,0.003889854,0.01536455,0.0004817826,0.00009785907,0.0002048298,0.0007784514,0.0004061594,0.008513823],"genre_scores_gemma":[0.9937856,0.0006774046,0.002820169,0.00009249045,0.00001469565,0.00007621448,0.0003527503,0.0000524749,0.002128191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002722606,"threshold_uncertainty_score":0.009107947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08349018879559977,"score_gpt":0.4323482356251277,"score_spread":0.3488580468295279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}